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FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation

Introduction: Ovarian follicle growth is a key step in the success of assisted reproductive treatment, but limited data exists to directly relate follicle growth to recombinant FSH (rFSH) dose. In this study, we aim to evaluate FSH requirements for follicular growth during controlled ovarian stimula...

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Autores principales: Abbara, Ali, Patel, Aaran, Hunjan, Tia, Clarke, Sophie A., Chia, Germaine, Eng, Pei Chia, Phylactou, Maria, Comninos, Alexander N., Lavery, Stuart, Trew, Geoffrey H., Salim, Rehan, Rai, Raj S., Kelsey, Tom W., Dhillo, Waljit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718557/
https://www.ncbi.nlm.nih.gov/pubmed/31507532
http://dx.doi.org/10.3389/fendo.2019.00579
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author Abbara, Ali
Patel, Aaran
Hunjan, Tia
Clarke, Sophie A.
Chia, Germaine
Eng, Pei Chia
Phylactou, Maria
Comninos, Alexander N.
Lavery, Stuart
Trew, Geoffrey H.
Salim, Rehan
Rai, Raj S.
Kelsey, Tom W.
Dhillo, Waljit S.
author_facet Abbara, Ali
Patel, Aaran
Hunjan, Tia
Clarke, Sophie A.
Chia, Germaine
Eng, Pei Chia
Phylactou, Maria
Comninos, Alexander N.
Lavery, Stuart
Trew, Geoffrey H.
Salim, Rehan
Rai, Raj S.
Kelsey, Tom W.
Dhillo, Waljit S.
author_sort Abbara, Ali
collection PubMed
description Introduction: Ovarian follicle growth is a key step in the success of assisted reproductive treatment, but limited data exists to directly relate follicle growth to recombinant FSH (rFSH) dose. In this study, we aim to evaluate FSH requirements for follicular growth during controlled ovarian stimulation. Method: Single center retrospective cohort study of 1,034 IVF cycles conducted between January 2012–January 2016 at Hammersmith Hospital IVF unit, London, UK. Median follicle size after 5 days of stimulation with rFSH and the proportion of antral follicles recruited were analyzed in women treated with rFSH alone to induce follicular growth during IVF treatment. Results: Starting rFSH dose adjusted for body weight (iU/kg) predicted serum FSH level after 5 days of rFSH (r(2) = 0.352, p < 0.0001), median follicle size after 5 days of rFSH, and the proportion of antral follicles recruited by the end of stimulation. Day 5 median follicle size predicted median follicle size on subsequent ultrasound scans (r(2) = 0.58–0.62; p < 0.0001), and hence time to oocyte maturation trigger (r(2) = 0.22, P < 0.0001). Insufficient rFSH starting dose that required >5% dose-increase was associated with increased variability in follicle size on the day of oocyte maturation trigger, and negatively impacted the number of mature oocytes retrieved. Conclusion: Weight-adjusted rFSH dose correlates with follicular growth during ovarian stimulation. Early recruitment of follicles using a sufficient dose of rFSH from the start of stimulation was associated with reduced variability in follicle size at time of oocyte maturation trigger and an increased number of mature oocytes retrieved.
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spelling pubmed-67185572019-09-10 FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation Abbara, Ali Patel, Aaran Hunjan, Tia Clarke, Sophie A. Chia, Germaine Eng, Pei Chia Phylactou, Maria Comninos, Alexander N. Lavery, Stuart Trew, Geoffrey H. Salim, Rehan Rai, Raj S. Kelsey, Tom W. Dhillo, Waljit S. Front Endocrinol (Lausanne) Endocrinology Introduction: Ovarian follicle growth is a key step in the success of assisted reproductive treatment, but limited data exists to directly relate follicle growth to recombinant FSH (rFSH) dose. In this study, we aim to evaluate FSH requirements for follicular growth during controlled ovarian stimulation. Method: Single center retrospective cohort study of 1,034 IVF cycles conducted between January 2012–January 2016 at Hammersmith Hospital IVF unit, London, UK. Median follicle size after 5 days of stimulation with rFSH and the proportion of antral follicles recruited were analyzed in women treated with rFSH alone to induce follicular growth during IVF treatment. Results: Starting rFSH dose adjusted for body weight (iU/kg) predicted serum FSH level after 5 days of rFSH (r(2) = 0.352, p < 0.0001), median follicle size after 5 days of rFSH, and the proportion of antral follicles recruited by the end of stimulation. Day 5 median follicle size predicted median follicle size on subsequent ultrasound scans (r(2) = 0.58–0.62; p < 0.0001), and hence time to oocyte maturation trigger (r(2) = 0.22, P < 0.0001). Insufficient rFSH starting dose that required >5% dose-increase was associated with increased variability in follicle size on the day of oocyte maturation trigger, and negatively impacted the number of mature oocytes retrieved. Conclusion: Weight-adjusted rFSH dose correlates with follicular growth during ovarian stimulation. Early recruitment of follicles using a sufficient dose of rFSH from the start of stimulation was associated with reduced variability in follicle size at time of oocyte maturation trigger and an increased number of mature oocytes retrieved. Frontiers Media S.A. 2019-08-27 /pmc/articles/PMC6718557/ /pubmed/31507532 http://dx.doi.org/10.3389/fendo.2019.00579 Text en Copyright © 2019 Abbara, Patel, Hunjan, Clarke, Chia, Eng, Phylactou, Comninos, Lavery, Trew, Salim, Rai, Kelsey and Dhillo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Abbara, Ali
Patel, Aaran
Hunjan, Tia
Clarke, Sophie A.
Chia, Germaine
Eng, Pei Chia
Phylactou, Maria
Comninos, Alexander N.
Lavery, Stuart
Trew, Geoffrey H.
Salim, Rehan
Rai, Raj S.
Kelsey, Tom W.
Dhillo, Waljit S.
FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
title FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
title_full FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
title_fullStr FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
title_full_unstemmed FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
title_short FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
title_sort fsh requirements for follicle growth during controlled ovarian stimulation
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718557/
https://www.ncbi.nlm.nih.gov/pubmed/31507532
http://dx.doi.org/10.3389/fendo.2019.00579
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