Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside

Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of adverse events, it is now considered to be a suitable therapeutic alternative in most guidelines. Experimental studies suggest that SCS may als...

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Detalles Bibliográficos
Autores principales: Fonoff, Erich Talamoni, de Lima-Pardini, Andrea C., Coelho, Daniel Boari, Monaco, Bernardo Assumpção, Machado, Birajara, Pinto de Souza, Carolina, dos Santos Ghilardi, Maria Gabriela, Hamani, Clement
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718563/
https://www.ncbi.nlm.nih.gov/pubmed/31507514
http://dx.doi.org/10.3389/fneur.2019.00905
Descripción
Sumario:Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of adverse events, it is now considered to be a suitable therapeutic alternative in most guidelines. Experimental studies suggest that SCS may also be used as a therapy for motor and gait dysfunction in parkinsonian states. The most common and disabling gait dysfunction in patients with Parkinson's disease (PD) is freezing of gait (FoG). We review the evolution of SCS for gait disorders from bench to bedside and discuss potential mechanisms of action, neural substrates, and clinical outcomes.

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