Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside

Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of adverse events, it is now considered to be a suitable therapeutic alternative in most guidelines. Experimental studies suggest that SCS may als...

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Autores principales: Fonoff, Erich Talamoni, de Lima-Pardini, Andrea C., Coelho, Daniel Boari, Monaco, Bernardo Assumpção, Machado, Birajara, Pinto de Souza, Carolina, dos Santos Ghilardi, Maria Gabriela, Hamani, Clement
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718563/
https://www.ncbi.nlm.nih.gov/pubmed/31507514
http://dx.doi.org/10.3389/fneur.2019.00905
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author Fonoff, Erich Talamoni
de Lima-Pardini, Andrea C.
Coelho, Daniel Boari
Monaco, Bernardo Assumpção
Machado, Birajara
Pinto de Souza, Carolina
dos Santos Ghilardi, Maria Gabriela
Hamani, Clement
author_facet Fonoff, Erich Talamoni
de Lima-Pardini, Andrea C.
Coelho, Daniel Boari
Monaco, Bernardo Assumpção
Machado, Birajara
Pinto de Souza, Carolina
dos Santos Ghilardi, Maria Gabriela
Hamani, Clement
author_sort Fonoff, Erich Talamoni
collection PubMed
description Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of adverse events, it is now considered to be a suitable therapeutic alternative in most guidelines. Experimental studies suggest that SCS may also be used as a therapy for motor and gait dysfunction in parkinsonian states. The most common and disabling gait dysfunction in patients with Parkinson's disease (PD) is freezing of gait (FoG). We review the evolution of SCS for gait disorders from bench to bedside and discuss potential mechanisms of action, neural substrates, and clinical outcomes.
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spelling pubmed-67185632019-09-10 Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside Fonoff, Erich Talamoni de Lima-Pardini, Andrea C. Coelho, Daniel Boari Monaco, Bernardo Assumpção Machado, Birajara Pinto de Souza, Carolina dos Santos Ghilardi, Maria Gabriela Hamani, Clement Front Neurol Neurology Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of adverse events, it is now considered to be a suitable therapeutic alternative in most guidelines. Experimental studies suggest that SCS may also be used as a therapy for motor and gait dysfunction in parkinsonian states. The most common and disabling gait dysfunction in patients with Parkinson's disease (PD) is freezing of gait (FoG). We review the evolution of SCS for gait disorders from bench to bedside and discuss potential mechanisms of action, neural substrates, and clinical outcomes. Frontiers Media S.A. 2019-08-27 /pmc/articles/PMC6718563/ /pubmed/31507514 http://dx.doi.org/10.3389/fneur.2019.00905 Text en Copyright © 2019 Fonoff, de Lima-Pardini, Coelho, Monaco, Machado, Pinto de Souza, dos Santos Ghilardi and Hamani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Fonoff, Erich Talamoni
de Lima-Pardini, Andrea C.
Coelho, Daniel Boari
Monaco, Bernardo Assumpção
Machado, Birajara
Pinto de Souza, Carolina
dos Santos Ghilardi, Maria Gabriela
Hamani, Clement
Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
title Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
title_full Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
title_fullStr Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
title_full_unstemmed Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
title_short Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
title_sort spinal cord stimulation for freezing of gait: from bench to bedside
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718563/
https://www.ncbi.nlm.nih.gov/pubmed/31507514
http://dx.doi.org/10.3389/fneur.2019.00905
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