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Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

The study of Hutchinson–Gilford progeria syndrome (HGPS) has provided important clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts nuclear envelope structure/function, with further impairment of multiple processes that culminate in senescence. Here, we demonstrate th...

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Detalles Bibliográficos
Autores principales: García‐Aguirre, Ian, Alamillo‐Iniesta, Alma, Rodríguez‐Pérez, Ruth, Vélez‐Aguilera, Griselda, Amaro‐Encarnación, Elianeth, Jiménez‐Gutiérrez, Elizabeth, Vásquez‐Limeta, Alejandra, Samuel Laredo‐Cisneros, Marco, Morales‐Lázaro, Sara L., Tiburcio‐Félix, Reynaldo, Ortega, Arturo, Magaña, Jonathan J, Winder, Steve J., Cisneros, Bulmaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718587/
https://www.ncbi.nlm.nih.gov/pubmed/31305018
http://dx.doi.org/10.1111/acel.13002

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