TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise most commonly in the setting of the Neurofibromatosis Type 1 (NF1) cancer predisposition syndrome. Despite aggressive multimodality therapy, outcomes are dismal and most patients die within 5 years of di...

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Detalles Bibliográficos
Autores principales: Qin, Wenjing, Godec, Abigail, Zhang, Xiaochun, Zhu, Cuige, Shao, Jieya, Tao, Yu, Bu, Xianzhang, Hirbe, Angela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718590/
https://www.ncbi.nlm.nih.gov/pubmed/31278855
http://dx.doi.org/10.1002/cam4.2386

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