Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells

Epigenetic alterations occur in various cells and tissues during aging, but it is not known if such alterations are also associated with aging in skeletal muscle. Here, we examined the changes of a panel of histone modifications and found H3K27ac (an active enhancer mark) is markedly increased in ag...

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Detalles Bibliográficos
Autores principales: Zhou, Jiajian, So, Karl K., Li, Yuying, Li, Yang, Yuan, Jie, Ding, Yingzhe, Chen, Fengyuan, Huang, Yile, Liu, Jin, Lee, Wayne, Li, Gang, Ju, Zhenyu, Sun, Hao, Wang, Huating
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718601/
https://www.ncbi.nlm.nih.gov/pubmed/31325224
http://dx.doi.org/10.1111/acel.12996

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