Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

Polyketides produced by modular type I polyketide synthases (PKSs) play eminent roles in the development of medicines. Yet, the production of structural analogs by genetic engineering poses a major challenge. We report an evolution-guided morphing of modular PKSs inspired by recombination processes...

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Detalles Bibliográficos
Autores principales: Peng, Huiyun, Ishida, Keishi, Sugimoto, Yuki, Jenke-Kodama, Holger, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718629/
https://www.ncbi.nlm.nih.gov/pubmed/31477708
http://dx.doi.org/10.1038/s41467-019-11896-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718629/
https://www.ncbi.nlm.nih.gov/pubmed/31477708
http://dx.doi.org/10.1038/s41467-019-11896-1

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