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Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression

Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs....

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Detalles Bibliográficos
Autores principales:	Elam, Kit K., Clifford, Sierra, Shaw, Daniel S., Wilson, Melvin N., Lemery-Chalfant, Kathryn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718657/ https://www.ncbi.nlm.nih.gov/pubmed/31477688 http://dx.doi.org/10.1038/s41398-019-0513-7

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