Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration

Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that when upregulated in cancers enhances cell migration rates; however, the mechanism remains unknown. Previous work identified AqB011 as an inhibitor of the gated human AQP1 cation conductance, and bacopaside II as a blocker o...

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Detalles Bibliográficos
Autores principales: De Ieso, Michael L., Pei, Jinxin V., Nourmohammadi, Saeed, Smith, Eric, Chow, Pak Hin, Kourghi, Mohamad, Hardingham, Jennifer E., Yool, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718670/
https://www.ncbi.nlm.nih.gov/pubmed/31477744
http://dx.doi.org/10.1038/s41598-019-49045-9

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