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High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice

The accumulation of human islet amyloid polypeptide (hIAPP) in pancreatic islets under induction by a high-fat diet plays a critical role in the development of type-2 diabetes mellitus (T2DM). T2DM is a risk factor of late-onset Alzheimer’s disease (AD). Nevertheless, whether hIAPP in combination wi...

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Detalles Bibliográficos
Autores principales:	Xi, Xiao-Xia, Sun, Jing, Chen, Hai-Chao, Chen, An-Di, Gao, Li-Ping, Yin, Jie, Jing, Yu-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718729/ https://www.ncbi.nlm.nih.gov/pubmed/31507407 http://dx.doi.org/10.3389/fnagi.2019.00225

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