Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer

Unexpectedly, the synthetic antioxidant MnTBAP was found to cause a rapid and reversible downregulation of CD4 on T cells in vitro and in vivo. This effect resulted from the internalization of membrane CD4 T cell molecules into clathrin-coated pits and involved disruption of the CD4/p56(Lck) complex...

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Detalles Bibliográficos
Autores principales: Da Rocha, Sylvie, Bigot, Jérémy, Onodi, Fanny, Cosette, Jérémie, Corre, Guillaume, Poupiot, Jérôme, Fenard, David, Gjata, Bernard, Galy, Anne, Neildez-Nguyen, Thi My Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718808/
https://www.ncbi.nlm.nih.gov/pubmed/31497619
http://dx.doi.org/10.1016/j.omtm.2019.06.011

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