Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant

Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal fibroblasts (HDFs), fibroblast growth factor (FGF) and transforming growth factor β (TGF-β) signaling oppositely modulate multiple CAF effector genes....

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Detalles Bibliográficos
Autores principales: Bordignon, Pino, Bottoni, Giulia, Xu, Xiaoying, Popescu, Alma S., Truan, Zinnia, Guenova, Emmanuella, Kofler, Lukas, Jafari, Paris, Ostano, Paola, Röcken, Martin, Neel, Victor, Dotto, G. Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718812/
https://www.ncbi.nlm.nih.gov/pubmed/31461652
http://dx.doi.org/10.1016/j.celrep.2019.07.092

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