Cargando…

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism in tumors in vivo remains unexplored. Using murine i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aguilar, Esther, Esteves, Pauline, Sancerni, Tiphaine, Lenoir, Véronique, Aparicio, Thomas, Bouillaud, Frédéric, Dentin, Renaud, Prip-Buus, Carina, Ricquier, Daniel, Pecqueur, Claire, Guilmeau, Sandra, Alves-Guerra, Marie-Clotilde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718829/ https://www.ncbi.nlm.nih.gov/pubmed/31461648 http://dx.doi.org/10.1016/j.celrep.2019.07.097

Ejemplares similares

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling
por: Sancerni, Tiphaine, et al.
Publicado: (2022)

UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells
por: Esteves, Pauline, et al.
Publicado: (2014)

Analysis of Uncoupling Protein 2-Deficient Mice upon Anaesthesia and Sedation Revealed a Role for UCP2 in Locomotion
por: Alves-Guerra, Marie-Clotilde, et al.
Publicado: (2012)

Mutations in UCP2 in Congenital Hyperinsulinism Reveal a Role for Regulation of Insulin Secretion
por: González-Barroso, M. Mar, et al.
Publicado: (2008)

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
por: Bricambert, Julien, et al.
Publicado: (2018)

Deletion of UCP2 in iNOS Deficient Mice Reduces the Severity of the Disease during Experimental Autoimmune Encephalomyelitis
por: Aheng, Caroline, et al.
Publicado: (2011)

Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease
por: Mateus, Inês, et al.
Publicado: (2021)

Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
por: Gagelin, Antoine, et al.
Publicado: (2023)

New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis
por: Robbins, Delira, et al.
Publicado: (2011)

Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2
por: Yin, Cong, et al.
Publicado: (2021)

Correlation Between Pancreatic Islet Uncoupling Protein-2 (UCP2) mRNA Concentration And Insulin Status in Rats
por: Kassis, Nadim, et al.
Publicado: (2000)

Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis
por: Savall, Mathilde, et al.
Publicado: (2021)

NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury
por: Almyroudis, Nikolaos G., et al.
Publicado: (2013)

The defense and signaling role of NADPH oxidases in eukaryotic cells: Review
por: Breitenbach, Michael, et al.
Publicado: (2018)

Oncogene-induced NAD(+) depletion in tumorigenesis
por: Tummala, Krishna S., et al.
Publicado: (2015)

UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control
por: Luby, Angèle, et al.
Publicado: (2022)

Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity
por: Kukat, Alexandra, et al.
Publicado: (2014)

Tumorigenesis: Cell Defense Against Hypoxia?
por: Pakravan, Nafiseh
Publicado: (2013)

Role of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense
por: Vethanayagam, R. Robert, et al.
Publicado: (2011)

Stress defense mechanisms of NADPH-dependent thioredoxin reductases (NTRs) in plants
por: Cha, Joon-Yung, et al.
Publicado: (2015)

Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion
por: Zhang, Congyi, et al.
Publicado: (2022)

UCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells
por: Li, Yunfeng, et al.
Publicado: (2008)

Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia
por: Nikanorova, Alena A., et al.
Publicado: (2022)

NADH and NADPH peroxidases as antioxidant defense mechanisms in intestinal sulfate-reducing bacteria
por: Kushkevych, Ivan, et al.
Publicado: (2023)

Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione
por: Kilanczyk, Ewa, et al.
Publicado: (2016)

Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis
por: Lee, Suho, et al.
Publicado: (2015)

UCP1 and UCP3 Expression Is Associated with Lipid and Carbohydrate Oxidation and Body Composition
por: Oliveira, Bruno A. P., et al.
Publicado: (2016)

The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue
por: Hilse, Karolina E., et al.
Publicado: (2016)

Correction: UCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells
por: Li, Yunfeng, et al.
Publicado: (2022)

Impaired energy metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes
por: Baraibar, Martín A., et al.
Publicado: (2016)

UCP2 and UCP3 polymorphisms as risk factors of insulin resistance for Indonesian obese adolescents
por: Mexitalia, M, et al.
Publicado: (2013)

Erratum to: Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis
por: Lee, Suho, et al.
Publicado: (2015)

Berberine regulates UCP1 expression by reshaping the conformation of quadruplex formed by the element of the UCP1 gene promoter : Berberine, a novel regulator of UCP-1
por: Wang, Qiuhui, et al.
Publicado: (2022)

Depletion of CDC5L inhibits bladder cancer tumorigenesis
por: Zhang, Ziwei, et al.
Publicado: (2020)

H(2)O(2) Metabolism in Normal Thyroid Cells and in Thyroid Tumorigenesis: Focus on NADPH Oxidases
por: Szanto, Ildiko, et al.
Publicado: (2019)

Important Trends in UCP3 Investigation
por: Pohl, Elena E., et al.
Publicado: (2019)

Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue
por: Shore, A., et al.
Publicado: (2010)

SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure
por: Figueroa-Vega, Nicté, et al.
Publicado: (2020)

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease
por: Huesca-Gómez, Claudia, et al.
Publicado: (2023)

Depletion of CDC5L inhibits bladder cancer tumorigenesis: Erratum
por: Zhang, Ziwei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gm2bofs8hecvv8uq8v0gto6e10