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Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study

BACKGROUND: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes. OBJECTIVE: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restrictio...

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Autores principales: Can Ibanoglu, Mujde, Yasar Sanhal, Cem, Ozgu-Erdinc, Seval, Kara, Ozgur, Yucel, Aykan, Uygur, Dilek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718885/
https://www.ncbi.nlm.nih.gov/pubmed/31508574
http://dx.doi.org/10.18502/ijrm.v17i7.4860
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author Can Ibanoglu, Mujde
Yasar Sanhal, Cem
Ozgu-Erdinc, Seval
Kara, Ozgur
Yucel, Aykan
Uygur, Dilek
author_facet Can Ibanoglu, Mujde
Yasar Sanhal, Cem
Ozgu-Erdinc, Seval
Kara, Ozgur
Yucel, Aykan
Uygur, Dilek
author_sort Can Ibanoglu, Mujde
collection PubMed
description BACKGROUND: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes. OBJECTIVE: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restriction (FGR). MATERIALS AND METHODS: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis. RESULTS: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19.3 [Formula: see text] 3.0 ng/ml vs 25.9 [Formula: see text] 6.8 ng/ml, p = 0.001). Area under receiver operating characteristic curve analysis of FA in FGR was 0.815 (95% confidence interval (CI): 0.718-0.912, p [Formula: see text] 0.001). The maternal FA levels with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79-85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30), respectively. Therefore, the diagnostic accuracy was obtained about 77.78%. CONCLUSION: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR.
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spelling pubmed-67188852019-09-10 Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study Can Ibanoglu, Mujde Yasar Sanhal, Cem Ozgu-Erdinc, Seval Kara, Ozgur Yucel, Aykan Uygur, Dilek Int J Reprod Biomed Research Article BACKGROUND: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes. OBJECTIVE: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restriction (FGR). MATERIALS AND METHODS: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis. RESULTS: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19.3 [Formula: see text] 3.0 ng/ml vs 25.9 [Formula: see text] 6.8 ng/ml, p = 0.001). Area under receiver operating characteristic curve analysis of FA in FGR was 0.815 (95% confidence interval (CI): 0.718-0.912, p [Formula: see text] 0.001). The maternal FA levels with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79-85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30), respectively. Therefore, the diagnostic accuracy was obtained about 77.78%. CONCLUSION: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR. Knowledge E 2019-07-31 /pmc/articles/PMC6718885/ /pubmed/31508574 http://dx.doi.org/10.18502/ijrm.v17i7.4860 Text en Copyright © 2019 Mujde Can Ibanoglu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Article
Can Ibanoglu, Mujde
Yasar Sanhal, Cem
Ozgu-Erdinc, Seval
Kara, Ozgur
Yucel, Aykan
Uygur, Dilek
Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study
title Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study
title_full Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study
title_fullStr Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study
title_full_unstemmed Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study
title_short Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study
title_sort maternal plasma fetuin-a levels in fetal growth restriction: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718885/
https://www.ncbi.nlm.nih.gov/pubmed/31508574
http://dx.doi.org/10.18502/ijrm.v17i7.4860
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