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GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

BACKGROUND & AIMS: GPBAR1, also known as TGR5, is a G protein–coupled receptor activated by bile acids. Hepatic innate immune cells are involved in the immunopathogenesis of human liver diseases and in several murine hepatitis models. Here, by using genetic and pharmacological approaches, we pro...

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Detalles Bibliográficos
Autores principales:	Biagioli, Michele, Carino, Adriana, Fiorucci, Chiara, Marchianò, Silvia, Di Giorgio, Cristina, Roselli, Rosalinda, Magro, Margherita, Distrutti, Eleonora, Bereshchenko, Oxana, Scarpelli, Paolo, Zampella, Angela, Fiorucci, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718949/ https://www.ncbi.nlm.nih.gov/pubmed/31226434 http://dx.doi.org/10.1016/j.jcmgh.2019.06.003

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