First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae

Novel antimicrobial classes are in desperate need for clinical management of infections caused by increasingly prevalent multi-drug resistant pathogens. The protein-protein interaction between bacterial RNA polymerase (RNAP) and the housekeeping sigma initiation factor is essential to transcription...

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Detalles Bibliográficos
Autores principales: Ye, Jiqing, Chu, Adrian Jun, Lin, Lin, Yang, Xiao, Ma, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719014/
https://www.ncbi.nlm.nih.gov/pubmed/31405060
http://dx.doi.org/10.3390/molecules24162902

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