Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Antibacterial lysins are promising proteins that are active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial lysins is their fast elimination from systemic circulation. PEGylation increases the plasma half-life of lysins but...

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Detalles Bibliográficos
Autores principales: Grishin, Alexander V., Shestak, Nikita V., Lavrova, Natalia V., Lyashchuk, Alexander M., Popova, Liubov I., Strukova, Natalia V., Generalova, Maria S., Ryazanova, Anna V., Polyakov, Nikita B., Galushkina, Zoya M., Soboleva, Lyubov A., Boksha, Irina S., Karyagina, Anna S., Lunin, Vladimir G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719061/
https://www.ncbi.nlm.nih.gov/pubmed/31395814
http://dx.doi.org/10.3390/molecules24162892

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