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Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign microwave technology. The contemporary presen...

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Detalles Bibliográficos
Autores principales:	Maiuolo, Loredana, Algieri, Vincenzo, Russo, Beatrice, Tallarida, Matteo Antonio, Nardi, Monica, Di Gioia, Maria Luisa, Merchant, Zahra, Merino, Pedro, Delso, Ignacio, De Nino, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719244/ https://www.ncbi.nlm.nih.gov/pubmed/31405162 http://dx.doi.org/10.3390/molecules24162909

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