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‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’

Hepatitis C virus (HCV) represents a major public health problem, while the identification of a HCV genotype is clinically very important for therapy prescription. The aim of the present study was to determine the HCV genotype distribution patients from northern Greece with HCV RNA positive viral lo...

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Autores principales: Gioula, G., Sinakos, E., Gigi, E., Goulis, I., Vasiliadis, T., Minti, F., Akriviadis, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719250/
https://www.ncbi.nlm.nih.gov/pubmed/31516719
http://dx.doi.org/10.1017/gheg.2019.4
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author Gioula, G.
Sinakos, E.
Gigi, E.
Goulis, I.
Vasiliadis, T.
Minti, F.
Akriviadis, E.
author_facet Gioula, G.
Sinakos, E.
Gigi, E.
Goulis, I.
Vasiliadis, T.
Minti, F.
Akriviadis, E.
author_sort Gioula, G.
collection PubMed
description Hepatitis C virus (HCV) represents a major public health problem, while the identification of a HCV genotype is clinically very important for therapy prescription. The aim of the present study was to determine the HCV genotype distribution patients from northern Greece with HCV RNA positive viral load and to identify whether there is a shift in this distribution, during 2009–2017. The study was performed on 915 HCV positive patients and according to the results, genotype 3 was the most prevalent genotype (Ν = 395, 43.2%) followed by genotype 1 (Ν = 361, 39.5%). Regarding the gender of the patients, genotype 1 was mostly detected in women. Moreover, genotype 1 was associated with higher viral loads, while genotype 3 was most frequently detected in patients with a history of intravenous drug use. In conclusion, our results show that genotype 3 is the most prevalent genotype in Greece during the last decade as opposed to older epidemiological studies, likely due to intravenous drug use becoming the major source of infection.
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spelling pubmed-67192502019-09-12 ‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’ Gioula, G. Sinakos, E. Gigi, E. Goulis, I. Vasiliadis, T. Minti, F. Akriviadis, E. Glob Health Epidemiol Genom Original Research Article Hepatitis C virus (HCV) represents a major public health problem, while the identification of a HCV genotype is clinically very important for therapy prescription. The aim of the present study was to determine the HCV genotype distribution patients from northern Greece with HCV RNA positive viral load and to identify whether there is a shift in this distribution, during 2009–2017. The study was performed on 915 HCV positive patients and according to the results, genotype 3 was the most prevalent genotype (Ν = 395, 43.2%) followed by genotype 1 (Ν = 361, 39.5%). Regarding the gender of the patients, genotype 1 was mostly detected in women. Moreover, genotype 1 was associated with higher viral loads, while genotype 3 was most frequently detected in patients with a history of intravenous drug use. In conclusion, our results show that genotype 3 is the most prevalent genotype in Greece during the last decade as opposed to older epidemiological studies, likely due to intravenous drug use becoming the major source of infection. Cambridge University Press 2019-09-02 /pmc/articles/PMC6719250/ /pubmed/31516719 http://dx.doi.org/10.1017/gheg.2019.4 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Gioula, G.
Sinakos, E.
Gigi, E.
Goulis, I.
Vasiliadis, T.
Minti, F.
Akriviadis, E.
‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’
title ‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’
title_full ‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’
title_fullStr ‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’
title_full_unstemmed ‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’
title_short ‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’
title_sort ‘distribution of hepatitis c virus genotypes in northern greece in the last decade: descriptive analysis and clinical correlations’
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719250/
https://www.ncbi.nlm.nih.gov/pubmed/31516719
http://dx.doi.org/10.1017/gheg.2019.4
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