Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report

We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy...

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Autores principales: Mutnuri, Sangeeta, Kassem, Hania, Badalamenti, John, Qian, You-Wen, Marquez, Christopher, Afrouzian, Marjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719345/
https://www.ncbi.nlm.nih.gov/pubmed/31531252
http://dx.doi.org/10.1155/2019/7940291
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author Mutnuri, Sangeeta
Kassem, Hania
Badalamenti, John
Qian, You-Wen
Marquez, Christopher
Afrouzian, Marjan
author_facet Mutnuri, Sangeeta
Kassem, Hania
Badalamenti, John
Qian, You-Wen
Marquez, Christopher
Afrouzian, Marjan
author_sort Mutnuri, Sangeeta
collection PubMed
description We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Our case raises awareness regarding possibility of monoclonality in the renal biopsy of HCV-infected patients and exemplifies the crucial role the renal biopsy plays in detecting lymphoid malignancies where clinical features are ambiguous.
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spelling pubmed-67193452019-09-17 Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report Mutnuri, Sangeeta Kassem, Hania Badalamenti, John Qian, You-Wen Marquez, Christopher Afrouzian, Marjan Case Rep Nephrol Case Report We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Our case raises awareness regarding possibility of monoclonality in the renal biopsy of HCV-infected patients and exemplifies the crucial role the renal biopsy plays in detecting lymphoid malignancies where clinical features are ambiguous. Hindawi 2019-08-18 /pmc/articles/PMC6719345/ /pubmed/31531252 http://dx.doi.org/10.1155/2019/7940291 Text en Copyright © 2019 Sangeeta Mutnuri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mutnuri, Sangeeta
Kassem, Hania
Badalamenti, John
Qian, You-Wen
Marquez, Christopher
Afrouzian, Marjan
Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
title Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
title_full Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
title_fullStr Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
title_full_unstemmed Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
title_short Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
title_sort lymphoma-associated monoclonal cryoglobulinemic glomerulonephritis and relationship with hepatitis c virus infection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719345/
https://www.ncbi.nlm.nih.gov/pubmed/31531252
http://dx.doi.org/10.1155/2019/7940291
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