Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart

The hypothetical trigger of remote postconditioning (RPost) of the heart is the high-molecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study....

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Autores principales: Maslov, Leonid N., Tsibulnikov, Sergey Y., Prokudina, Ekaterina S., Popov, Sergey V., Boshchenko, Alla A., Singh, Nirmal, Zhang, Yi, Oeltgen, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719390/
https://www.ncbi.nlm.nih.gov/pubmed/30813880
http://dx.doi.org/10.2174/1573403X15666190226095820
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author Maslov, Leonid N.
Tsibulnikov, Sergey Y.
Prokudina, Ekaterina S.
Popov, Sergey V.
Boshchenko, Alla A.
Singh, Nirmal
Zhang, Yi
Oeltgen, Peter R.
author_facet Maslov, Leonid N.
Tsibulnikov, Sergey Y.
Prokudina, Ekaterina S.
Popov, Sergey V.
Boshchenko, Alla A.
Singh, Nirmal
Zhang, Yi
Oeltgen, Peter R.
author_sort Maslov, Leonid N.
collection PubMed
description The hypothetical trigger of remote postconditioning (RPost) of the heart is the high-molecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.
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spelling pubmed-67193902020-08-01 Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart Maslov, Leonid N. Tsibulnikov, Sergey Y. Prokudina, Ekaterina S. Popov, Sergey V. Boshchenko, Alla A. Singh, Nirmal Zhang, Yi Oeltgen, Peter R. Curr Cardiol Rev Article The hypothetical trigger of remote postconditioning (RPost) of the heart is the high-molecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel. Bentham Science Publishers 2019-08 2019-08 /pmc/articles/PMC6719390/ /pubmed/30813880 http://dx.doi.org/10.2174/1573403X15666190226095820 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Maslov, Leonid N.
Tsibulnikov, Sergey Y.
Prokudina, Ekaterina S.
Popov, Sergey V.
Boshchenko, Alla A.
Singh, Nirmal
Zhang, Yi
Oeltgen, Peter R.
Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
title Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
title_full Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
title_fullStr Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
title_full_unstemmed Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
title_short Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
title_sort trigger, signaling mechanism and end effector of cardioprotective effect of remote postconditioning of heart
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719390/
https://www.ncbi.nlm.nih.gov/pubmed/30813880
http://dx.doi.org/10.2174/1573403X15666190226095820
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