NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

NK cells eliminate virus-infected and tumor cells by releasing cytotoxic granules containing granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The orchestrated interplay between both cell death pathways remains poorly defined. Here we simultaneously measure the activit...

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Detalles Bibliográficos
Autores principales: Prager, Isabel, Liesche, Clarissa, van Ooijen, Hanna, Urlaub, Doris, Verron, Quentin, Sandström, Niklas, Fasbender, Frank, Claus, Maren, Eils, Roland, Beaudouin, Joël, Önfelt, Björn, Watzl, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719417/
https://www.ncbi.nlm.nih.gov/pubmed/31270246
http://dx.doi.org/10.1084/jem.20181454

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