Severe influenza pneumonitis in children with inherited TLR3 deficiency

Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and underlie severe influenza pneumonitis. We report three unrelated children with influenza A virus (IAV) infection manifesting as acute respiratory distress syndrome (IAV-ARDS), heterozygous for rare TLR3 variants (P...

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Detalles Bibliográficos
Autores principales: Lim, Hye Kyung, Huang, Sarah X.L., Chen, Jie, Kerner, Gaspard, Gilliaux, Olivier, Bastard, Paul, Dobbs, Kerry, Hernandez, Nicholas, Goudin, Nicolas, Hasek, Mary L., García Reino, Eduardo Javier, Lafaille, Fabien G., Lorenzo, Lazaro, Luthra, Priya, Kochetkov, Tatiana, Bigio, Benedetta, Boucherit, Soraya, Rozenberg, Flore, Vedrinne, Catherine, Keller, Michael D., Itan, Yuval, García-Sastre, Adolfo, Celard, Marie, Orange, Jordan S., Ciancanelli, Michael J., Meyts, Isabelle, Zhang, Qian, Abel, Laurent, Notarangelo, Luigi D., Snoeck, Hans-Willem, Casanova, Jean-Laurent, Zhang, Shen-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719423/
https://www.ncbi.nlm.nih.gov/pubmed/31217193
http://dx.doi.org/10.1084/jem.20181621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719423/
https://www.ncbi.nlm.nih.gov/pubmed/31217193
http://dx.doi.org/10.1084/jem.20181621

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