Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells

Conventional type 1 dendritic cells (cDC1s) are inherently resistant to many viruses but, paradoxically, possess fewer acidic phagosomes that enable antigen retention and cross-presentation. We report that palmitoyl-protein thioesterase 1 (PPT1), which catabolizes lipid-modified proteins in neurons,...

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Detalles Bibliográficos
Autores principales: Ou, Pengju, Wen, Lifen, Liu, Xiaoli, Huang, Jiancheng, Huang, Xiaoling, Su, Chaofei, Wang, Ling, Ni, Hai, Reizis, Boris, Yang, Cliff Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719428/
https://www.ncbi.nlm.nih.gov/pubmed/31262842
http://dx.doi.org/10.1084/jem.20190041

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