SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

SRC and ERK kinases control many cell biological processes that promote tumorigenesis by altering the activity of oncogenic and tumor suppressor proteins. We identify here a physiological interaction between DLC1, a focal adhesion protein and tumor suppressor, with SRC and ERK. The tumor suppressor...

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Detalles Bibliográficos
Autores principales: Tripathi, Brajendra K., Anderman, Meghan F., Qian, Xiaolan, Zhou, Ming, Wang, Dunrui, Papageorge, Alex G., Lowy, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719442/
https://www.ncbi.nlm.nih.gov/pubmed/31308216
http://dx.doi.org/10.1083/jcb.201810098

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