GTP-tubulin loves microtubule plus ends but marries the minus ends

Microtubule minus ends are inherently more stable than plus ends despite the fact that free tubulin associates more avidly to the plus end. In this issue, Strothman et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905019) measure, for the first time, the off-rate for GTP-tubulin and find t...

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Detalles Bibliográficos
Autor principal: Wordeman, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719450/
https://www.ncbi.nlm.nih.gov/pubmed/31427370
http://dx.doi.org/10.1083/jcb.201908039
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author Wordeman, Linda
author_facet Wordeman, Linda
author_sort Wordeman, Linda
collection PubMed
description Microtubule minus ends are inherently more stable than plus ends despite the fact that free tubulin associates more avidly to the plus end. In this issue, Strothman et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905019) measure, for the first time, the off-rate for GTP-tubulin and find that it is different for the two ends, suggesting that this parameter may control the transition to disassembly at microtubule ends.
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spelling pubmed-67194502020-03-02 GTP-tubulin loves microtubule plus ends but marries the minus ends Wordeman, Linda J Cell Biol Commentaries Microtubule minus ends are inherently more stable than plus ends despite the fact that free tubulin associates more avidly to the plus end. In this issue, Strothman et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905019) measure, for the first time, the off-rate for GTP-tubulin and find that it is different for the two ends, suggesting that this parameter may control the transition to disassembly at microtubule ends. Rockefeller University Press 2019-09-02 2019-08-19 /pmc/articles/PMC6719450/ /pubmed/31427370 http://dx.doi.org/10.1083/jcb.201908039 Text en © 2019 Wordeman http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Wordeman, Linda
GTP-tubulin loves microtubule plus ends but marries the minus ends
title GTP-tubulin loves microtubule plus ends but marries the minus ends
title_full GTP-tubulin loves microtubule plus ends but marries the minus ends
title_fullStr GTP-tubulin loves microtubule plus ends but marries the minus ends
title_full_unstemmed GTP-tubulin loves microtubule plus ends but marries the minus ends
title_short GTP-tubulin loves microtubule plus ends but marries the minus ends
title_sort gtp-tubulin loves microtubule plus ends but marries the minus ends
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719450/
https://www.ncbi.nlm.nih.gov/pubmed/31427370
http://dx.doi.org/10.1083/jcb.201908039
work_keys_str_mv AT wordemanlinda gtptubulinlovesmicrotubuleplusendsbutmarriestheminusends

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