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Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions

The DNA replication machinery frequently encounters impediments that slow replication fork progression and threaten timely and error-free replication. The CHK1 protein kinase is essential to deal with replication stress (RS) and ensure genome integrity and cell survival, yet how basal levels and act...

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Detalles Bibliográficos
Autores principales:	Michelena, Jone, Gatti, Marco, Teloni, Federico, Imhof, Ralph, Altmeyer, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719454/ https://www.ncbi.nlm.nih.gov/pubmed/31366665 http://dx.doi.org/10.1083/jcb.201902085

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