Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer...

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Detalles Bibliográficos
Autores principales: Kvainickas, Arunas, Nägele, Heike, Qi, Wenjing, Dokládal, Ladislav, Jimenez-Orgaz, Ana, Stehl, Luca, Gangurde, Dipak, Zhao, Qian, Hu, Zehan, Dengjel, Jörn, De Virgilio, Claudio, Baumeister, Ralf, Steinberg, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719456/
https://www.ncbi.nlm.nih.gov/pubmed/31431476
http://dx.doi.org/10.1083/jcb.201812110

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