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Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation

Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson’s disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of d...

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Detalles Bibliográficos
Autores principales: Tsai, Sheng-Tzung, Harn, Horng-Jyh, Lin, Shinn-Zong, Tseng, Guo-Fang, Chen, Shin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719490/
https://www.ncbi.nlm.nih.gov/pubmed/30298752
http://dx.doi.org/10.1177/0963689718804144
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author Tsai, Sheng-Tzung
Harn, Horng-Jyh
Lin, Shinn-Zong
Tseng, Guo-Fang
Chen, Shin-Yuan
author_facet Tsai, Sheng-Tzung
Harn, Horng-Jyh
Lin, Shinn-Zong
Tseng, Guo-Fang
Chen, Shin-Yuan
author_sort Tsai, Sheng-Tzung
collection PubMed
description Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson’s disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of deep brain stimulation for the treatment of neuropsychiatric disorders has shown great potential to modulate pathological neural circuits and trigger endogenous neurogenesis. We summarize several important clinical and translational studies that utilize deep brain stimulation to improve cognition based on the potentiation of neural plasticity and neurogenesis. In addition, we discuss the neuroanatomy and cerebral circuits implicated in such studies as well as the potential mechanisms underlying therapeutic benefits.
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spelling pubmed-67194902019-09-12 Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation Tsai, Sheng-Tzung Harn, Horng-Jyh Lin, Shinn-Zong Tseng, Guo-Fang Chen, Shin-Yuan Cell Transplant Reviews Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson’s disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of deep brain stimulation for the treatment of neuropsychiatric disorders has shown great potential to modulate pathological neural circuits and trigger endogenous neurogenesis. We summarize several important clinical and translational studies that utilize deep brain stimulation to improve cognition based on the potentiation of neural plasticity and neurogenesis. In addition, we discuss the neuroanatomy and cerebral circuits implicated in such studies as well as the potential mechanisms underlying therapeutic benefits. SAGE Publications 2018-10-09 2019-07 /pmc/articles/PMC6719490/ /pubmed/30298752 http://dx.doi.org/10.1177/0963689718804144 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Tsai, Sheng-Tzung
Harn, Horng-Jyh
Lin, Shinn-Zong
Tseng, Guo-Fang
Chen, Shin-Yuan
Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
title Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
title_full Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
title_fullStr Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
title_full_unstemmed Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
title_short Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
title_sort deep brain stimulation for amelioration of cognitive impairment in neurological disorders: neurogenesis and circuit reanimation
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719490/
https://www.ncbi.nlm.nih.gov/pubmed/30298752
http://dx.doi.org/10.1177/0963689718804144
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