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Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson’s disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719490/ https://www.ncbi.nlm.nih.gov/pubmed/30298752 http://dx.doi.org/10.1177/0963689718804144 |
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author | Tsai, Sheng-Tzung Harn, Horng-Jyh Lin, Shinn-Zong Tseng, Guo-Fang Chen, Shin-Yuan |
author_facet | Tsai, Sheng-Tzung Harn, Horng-Jyh Lin, Shinn-Zong Tseng, Guo-Fang Chen, Shin-Yuan |
author_sort | Tsai, Sheng-Tzung |
collection | PubMed |
description | Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson’s disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of deep brain stimulation for the treatment of neuropsychiatric disorders has shown great potential to modulate pathological neural circuits and trigger endogenous neurogenesis. We summarize several important clinical and translational studies that utilize deep brain stimulation to improve cognition based on the potentiation of neural plasticity and neurogenesis. In addition, we discuss the neuroanatomy and cerebral circuits implicated in such studies as well as the potential mechanisms underlying therapeutic benefits. |
format | Online Article Text |
id | pubmed-6719490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67194902019-09-12 Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation Tsai, Sheng-Tzung Harn, Horng-Jyh Lin, Shinn-Zong Tseng, Guo-Fang Chen, Shin-Yuan Cell Transplant Reviews Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson’s disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of deep brain stimulation for the treatment of neuropsychiatric disorders has shown great potential to modulate pathological neural circuits and trigger endogenous neurogenesis. We summarize several important clinical and translational studies that utilize deep brain stimulation to improve cognition based on the potentiation of neural plasticity and neurogenesis. In addition, we discuss the neuroanatomy and cerebral circuits implicated in such studies as well as the potential mechanisms underlying therapeutic benefits. SAGE Publications 2018-10-09 2019-07 /pmc/articles/PMC6719490/ /pubmed/30298752 http://dx.doi.org/10.1177/0963689718804144 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Reviews Tsai, Sheng-Tzung Harn, Horng-Jyh Lin, Shinn-Zong Tseng, Guo-Fang Chen, Shin-Yuan Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation |
title | Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation |
title_full | Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation |
title_fullStr | Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation |
title_full_unstemmed | Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation |
title_short | Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation |
title_sort | deep brain stimulation for amelioration of cognitive impairment in neurological disorders: neurogenesis and circuit reanimation |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719490/ https://www.ncbi.nlm.nih.gov/pubmed/30298752 http://dx.doi.org/10.1177/0963689718804144 |
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