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Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT
BACKGROUND: Adequate endometrial growth is principal for implantation and pregnancy. Thin endometrium is associated with lower pregnancy rate in assisted reproductive technology. Some frozen-thawed embryo transfer cycles are cancelled due to inadequate endometrial growth. OBJECTIVE: To assess the ef...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Knowledge E
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719514/ https://www.ncbi.nlm.nih.gov/pubmed/31508569 http://dx.doi.org/10.18502/ijrm.v17i6.4816 |
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author | Nazari, Leila Salehpour, Saghar Hoseini, Sedighe Zadehmodarres, Shahrzad Azargashb, Eznoallah |
author_facet | Nazari, Leila Salehpour, Saghar Hoseini, Sedighe Zadehmodarres, Shahrzad Azargashb, Eznoallah |
author_sort | Nazari, Leila |
collection | PubMed |
description | BACKGROUND: Adequate endometrial growth is principal for implantation and pregnancy. Thin endometrium is associated with lower pregnancy rate in assisted reproductive technology. Some frozen-thawed embryo transfer cycles are cancelled due to inadequate endometrial growth. OBJECTIVE: To assess the effectiveness of autologous platelet-rich plasma (PRP) intrauterine infusion for the treatment of thin endometrium. MATERIALS AND METHODS: A total of 72 patients who had a history of cancelled frozen-thawed embryo transfer cycle due to the thin endometrium ([Formula: see text] 7mm) were assessed for the eligibility to enter the study between 2016 and 2017. Twelve patients were excluded for different reasons, and 60 included patients were randomly assigned to PRP or sham-catheter groups in a double-blind manner. Hormone replacement therapy was administered for endometrial preparation in all participants. PRP intrauterine infusion or shamcatheter was performed on day 11-12 due to the thin endometrium and it was repeated after 48 hr if necessary. RESULTS: Endometrial thickness increased at 48 hr after the first intervention in both groups. All participants needed second intervention due to an inadequate endometrial expansion. After second intervention, endometrial thickness was 7.21 [Formula: see text] 0.18 and 5.76 [Formula: see text] 0.97 mm in the PRP group and sham-catheter group, respectively. There was a significant difference between the two groups. (p [Formula: see text] 0.001). Embryo transfer was done for all patients in PRP group and just in six cases in the sham-catheter group. Chemical pregnancy was reported in twelve cases in the PRP group and two cases in the sham-catheter group. CONCLUSION: According to this trial, PRP was effective in endometrial expansion in patients with refractory thin endometrium. |
format | Online Article Text |
id | pubmed-6719514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Knowledge E |
record_format | MEDLINE/PubMed |
spelling | pubmed-67195142019-09-10 Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT Nazari, Leila Salehpour, Saghar Hoseini, Sedighe Zadehmodarres, Shahrzad Azargashb, Eznoallah Int J Reprod Biomed Research Article BACKGROUND: Adequate endometrial growth is principal for implantation and pregnancy. Thin endometrium is associated with lower pregnancy rate in assisted reproductive technology. Some frozen-thawed embryo transfer cycles are cancelled due to inadequate endometrial growth. OBJECTIVE: To assess the effectiveness of autologous platelet-rich plasma (PRP) intrauterine infusion for the treatment of thin endometrium. MATERIALS AND METHODS: A total of 72 patients who had a history of cancelled frozen-thawed embryo transfer cycle due to the thin endometrium ([Formula: see text] 7mm) were assessed for the eligibility to enter the study between 2016 and 2017. Twelve patients were excluded for different reasons, and 60 included patients were randomly assigned to PRP or sham-catheter groups in a double-blind manner. Hormone replacement therapy was administered for endometrial preparation in all participants. PRP intrauterine infusion or shamcatheter was performed on day 11-12 due to the thin endometrium and it was repeated after 48 hr if necessary. RESULTS: Endometrial thickness increased at 48 hr after the first intervention in both groups. All participants needed second intervention due to an inadequate endometrial expansion. After second intervention, endometrial thickness was 7.21 [Formula: see text] 0.18 and 5.76 [Formula: see text] 0.97 mm in the PRP group and sham-catheter group, respectively. There was a significant difference between the two groups. (p [Formula: see text] 0.001). Embryo transfer was done for all patients in PRP group and just in six cases in the sham-catheter group. Chemical pregnancy was reported in twelve cases in the PRP group and two cases in the sham-catheter group. CONCLUSION: According to this trial, PRP was effective in endometrial expansion in patients with refractory thin endometrium. Knowledge E 2019-07-29 /pmc/articles/PMC6719514/ /pubmed/31508569 http://dx.doi.org/10.18502/ijrm.v17i6.4816 Text en Copyright © 2019 Leila Nazari et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Article Nazari, Leila Salehpour, Saghar Hoseini, Sedighe Zadehmodarres, Shahrzad Azargashb, Eznoallah Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT |
title | Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT |
title_full | Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT |
title_fullStr | Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT |
title_full_unstemmed | Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT |
title_short | Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT |
title_sort | effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: a double-blind rct |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719514/ https://www.ncbi.nlm.nih.gov/pubmed/31508569 http://dx.doi.org/10.18502/ijrm.v17i6.4816 |
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