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Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma
Diffuse Large B-cell Lymphoma, the most common adult non-Hodgkin lymphoma, is a proliferative neoplasm of enlarged B cells. Patients may be asymptomatic on presentation, but if present, symptoms often correlate with direct organ dysfunction resulting from the site of involvement. While the gastroint...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
São Paulo, SP: Universidade de São Paulo, Hospital Universitário
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719630/ https://www.ncbi.nlm.nih.gov/pubmed/31528629 http://dx.doi.org/10.4322/acr.2019.114 |
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author | Emanuel, Anthony Jacob Presnell, Susan Erin |
author_facet | Emanuel, Anthony Jacob Presnell, Susan Erin |
author_sort | Emanuel, Anthony Jacob |
collection | PubMed |
description | Diffuse Large B-cell Lymphoma, the most common adult non-Hodgkin lymphoma, is a proliferative neoplasm of enlarged B cells. Patients may be asymptomatic on presentation, but if present, symptoms often correlate with direct organ dysfunction resulting from the site of involvement. While the gastrointestinal system is the most common site of extranodal involvement, virtually any part of the body can be infiltrated by malignant lymphocytes. Here, we present an unusual case of cardiac and bilateral renal involvement by Diffuse Large B-cell Lymphoma in a 78-year-old male with a relatively unremarkable medical history. This combination of organ involvement and the resulting clinical symptoms are uncommonly described in the literature. The patient was treated for his symptoms prior to death, but the underlying cause that explained his presentation was not identified until performance of an autopsy. As such, this case demonstrates the utility of the medical autopsy, a gold standard in diagnostic medicine that can provide a variety of benefits in today’s healthcare system. |
format | Online Article Text |
id | pubmed-6719630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | São Paulo, SP: Universidade de São Paulo, Hospital Universitário |
record_format | MEDLINE/PubMed |
spelling | pubmed-67196302019-09-16 Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma Emanuel, Anthony Jacob Presnell, Susan Erin Autops Case Rep Article / Autopsy Case Report Diffuse Large B-cell Lymphoma, the most common adult non-Hodgkin lymphoma, is a proliferative neoplasm of enlarged B cells. Patients may be asymptomatic on presentation, but if present, symptoms often correlate with direct organ dysfunction resulting from the site of involvement. While the gastrointestinal system is the most common site of extranodal involvement, virtually any part of the body can be infiltrated by malignant lymphocytes. Here, we present an unusual case of cardiac and bilateral renal involvement by Diffuse Large B-cell Lymphoma in a 78-year-old male with a relatively unremarkable medical history. This combination of organ involvement and the resulting clinical symptoms are uncommonly described in the literature. The patient was treated for his symptoms prior to death, but the underlying cause that explained his presentation was not identified until performance of an autopsy. As such, this case demonstrates the utility of the medical autopsy, a gold standard in diagnostic medicine that can provide a variety of benefits in today’s healthcare system. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2019-09-02 /pmc/articles/PMC6719630/ /pubmed/31528629 http://dx.doi.org/10.4322/acr.2019.114 Text en Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited. |
spellingShingle | Article / Autopsy Case Report Emanuel, Anthony Jacob Presnell, Susan Erin Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma |
title | Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma |
title_full | Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma |
title_fullStr | Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma |
title_full_unstemmed | Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma |
title_short | Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma |
title_sort | acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large b-cell lymphoma |
topic | Article / Autopsy Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719630/ https://www.ncbi.nlm.nih.gov/pubmed/31528629 http://dx.doi.org/10.4322/acr.2019.114 |
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