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Non-obstetric complications in preeclampsia

Preeclampsia is a multisystem disorder of pregnancy that remains a leading cause of maternal and foetal morbidity and mortality. It is still an underestimated risk factor for future cardiovascular, cerebrovascular, and kidney disease, developing often in the perimenopausal period of a woman’s life....

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Autores principales: Pankiewicz, Katarzyna, Szczerba, Ewa, Maciejewski, Tomasz, Fijałkowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719635/
https://www.ncbi.nlm.nih.gov/pubmed/31485207
http://dx.doi.org/10.5114/pm.2019.85785
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author Pankiewicz, Katarzyna
Szczerba, Ewa
Maciejewski, Tomasz
Fijałkowska, Anna
author_facet Pankiewicz, Katarzyna
Szczerba, Ewa
Maciejewski, Tomasz
Fijałkowska, Anna
author_sort Pankiewicz, Katarzyna
collection PubMed
description Preeclampsia is a multisystem disorder of pregnancy that remains a leading cause of maternal and foetal morbidity and mortality. It is still an underestimated risk factor for future cardiovascular, cerebrovascular, and kidney disease, developing often in the perimenopausal period of a woman’s life. It remains unclear whether preeclampsia is an individual risk factor for future cardiovascular, cerebrovascular, and renal events or an early marker of women with high-risk profiles for these diseases. Risk factors for cardiovascular disorders and preeclampsia are very similar and include the following: obesity, dyslipidaemia, insulin resistance, pro-inflammatory and hypercoagulable state, and endothelial dysfunction. Thus, the pregnancy can only be a trigger for cardiovascular alterations that manifest in development of preeclampsia. On the other hand, there is strong evidence that changes in cardiovascular, endothelial, and metabolic systems occurring in the course of preeclampsia may not fully recover after delivery and can be a cause of future disease, especially in the presence of other metabolic risk factors regarding, for example, perimenopause. In this review the authors present current knowledge about short- and long-term maternal consequences of preeclampsia, such as: cardiovascular disease, cerebrovascular incidents (posterior reversible encephalopathy and stroke), kidney injury (including the risk of end-stage renal disease), liver failure, and coagulopathy (thrombocytopenia and disseminated intravascular coagulation).
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spelling pubmed-67196352019-09-04 Non-obstetric complications in preeclampsia Pankiewicz, Katarzyna Szczerba, Ewa Maciejewski, Tomasz Fijałkowska, Anna Prz Menopauzalny Review Paper Preeclampsia is a multisystem disorder of pregnancy that remains a leading cause of maternal and foetal morbidity and mortality. It is still an underestimated risk factor for future cardiovascular, cerebrovascular, and kidney disease, developing often in the perimenopausal period of a woman’s life. It remains unclear whether preeclampsia is an individual risk factor for future cardiovascular, cerebrovascular, and renal events or an early marker of women with high-risk profiles for these diseases. Risk factors for cardiovascular disorders and preeclampsia are very similar and include the following: obesity, dyslipidaemia, insulin resistance, pro-inflammatory and hypercoagulable state, and endothelial dysfunction. Thus, the pregnancy can only be a trigger for cardiovascular alterations that manifest in development of preeclampsia. On the other hand, there is strong evidence that changes in cardiovascular, endothelial, and metabolic systems occurring in the course of preeclampsia may not fully recover after delivery and can be a cause of future disease, especially in the presence of other metabolic risk factors regarding, for example, perimenopause. In this review the authors present current knowledge about short- and long-term maternal consequences of preeclampsia, such as: cardiovascular disease, cerebrovascular incidents (posterior reversible encephalopathy and stroke), kidney injury (including the risk of end-stage renal disease), liver failure, and coagulopathy (thrombocytopenia and disseminated intravascular coagulation). Termedia Publishing House 2019-06-14 2019-06 /pmc/articles/PMC6719635/ /pubmed/31485207 http://dx.doi.org/10.5114/pm.2019.85785 Text en Copyright: © 2019 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Pankiewicz, Katarzyna
Szczerba, Ewa
Maciejewski, Tomasz
Fijałkowska, Anna
Non-obstetric complications in preeclampsia
title Non-obstetric complications in preeclampsia
title_full Non-obstetric complications in preeclampsia
title_fullStr Non-obstetric complications in preeclampsia
title_full_unstemmed Non-obstetric complications in preeclampsia
title_short Non-obstetric complications in preeclampsia
title_sort non-obstetric complications in preeclampsia
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719635/
https://www.ncbi.nlm.nih.gov/pubmed/31485207
http://dx.doi.org/10.5114/pm.2019.85785
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