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Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome
Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719673/ https://www.ncbi.nlm.nih.gov/pubmed/31508200 http://dx.doi.org/10.12688/f1000research.19842.1 |
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author | Leverenz, David L. St. Clair, E. William |
author_facet | Leverenz, David L. St. Clair, E. William |
author_sort | Leverenz, David L. |
collection | PubMed |
description | Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development. |
format | Online Article Text |
id | pubmed-6719673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-67196732019-09-09 Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome Leverenz, David L. St. Clair, E. William F1000Res Review Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development. F1000 Research Limited 2019-08-29 /pmc/articles/PMC6719673/ /pubmed/31508200 http://dx.doi.org/10.12688/f1000research.19842.1 Text en Copyright: © 2019 Leverenz DL and St. Clair EW http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Leverenz, David L. St. Clair, E. William Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome |
title | Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome |
title_full | Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome |
title_fullStr | Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome |
title_full_unstemmed | Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome |
title_short | Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome |
title_sort | recent advances in the search for a targeted immunomodulatory therapy for primary sjögren’s syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719673/ https://www.ncbi.nlm.nih.gov/pubmed/31508200 http://dx.doi.org/10.12688/f1000research.19842.1 |
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