A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice

Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue and is associated with significant liver‐related morbidity and mortality. At present, there are no approved drug therapies for NASH. The transcriptional coactivator with PDZ‐binding motif (TAZ; encoded by WW domain‐contai...

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Detalles Bibliográficos
Autores principales: Wang, Xiaobo, Sommerfeld, Mark R., Jahn‐Hofmann, Kerstin, Cai, Bishuang, Filliol, Aveline, Remotti, Helen E., Schwabe, Robert F., Kannt, Aimo, Tabas, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719739/
https://www.ncbi.nlm.nih.gov/pubmed/31497743
http://dx.doi.org/10.1002/hep4.1405

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