Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study

OBJECTIVES: This pilot study aimed to 1) follow the longitudinal changes in the salivary oxytocin level of pregnant women from late pregnancy to early postpartum, 2) examine the factors related to these changes, and 3) clarify the association of these changes with mother-infant bonding. METHODS: Thi...

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Autores principales: Shishido, Eri, Shuo, Takuya, Takahata, Kaori, Horiuchi, Shigeko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719851/
https://www.ncbi.nlm.nih.gov/pubmed/31479475
http://dx.doi.org/10.1371/journal.pone.0221821
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author Shishido, Eri
Shuo, Takuya
Takahata, Kaori
Horiuchi, Shigeko
author_facet Shishido, Eri
Shuo, Takuya
Takahata, Kaori
Horiuchi, Shigeko
author_sort Shishido, Eri
collection PubMed
description OBJECTIVES: This pilot study aimed to 1) follow the longitudinal changes in the salivary oxytocin level of pregnant women from late pregnancy to early postpartum, 2) examine the factors related to these changes, and 3) clarify the association of these changes with mother-infant bonding. METHODS: This study used a longitudinal observational design and questionnaires to obtain objective and subjective data. For oxytocin evaluation, saliva samples were collected and their oxytocin levels were measured at 4-time points [i.e., 1) 36–37 gestation weeks, 2) 38–39 gestation weeks, 3) 1–2 days postpartum, 4) 4–5 days postpartum]. The oxytocin level was assayed in duplicates by enzyme-linked immunosorbent assay. Baseline data were evaluated using the Parental Bonding Instrument (25 items), State Trait Anxiety Inventory (20 items), and Center for Epidemiologic Studies Depression Scale. Postpartum data were evaluated using the Mother to Infant Bonding Scale Japanese Version (10 items), Maternity Blues Scale (13 items), and ‘Fatigue after Childbirth’ using the Visual Analogue Scale (VAS: 0–100 mm). RESULTS: The participants were 13 primiparas with a mean age of 33 years. They had no depression or anxiety at the baseline. Their mean salivary oxytocin levels significantly increased from late pregnancy (36–39 gestation weeks) up to 1 day postpartum and then decreased until 5 days postpartum. There was a negligible correlation between the bonding disorder and the salivary oxytocin level on the 5th day after childbirth. A moderate correlation was observed between the maternity blues score and the salivary oxytocin level. There was a significant negative correlation between the postpartum fatigue and the salivary oxytocin level 1 day and 5 days after childbirth. CONCLUSION: The mean salivary oxytocin levels significantly increased from the baseline up to 1 day postpartum and then decreased until 5 days postpartum. The salivary oxytocin level was moderately associated with maternity blues and significantly with postpartum fatigue.
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spelling pubmed-67198512019-09-16 Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study Shishido, Eri Shuo, Takuya Takahata, Kaori Horiuchi, Shigeko PLoS One Research Article OBJECTIVES: This pilot study aimed to 1) follow the longitudinal changes in the salivary oxytocin level of pregnant women from late pregnancy to early postpartum, 2) examine the factors related to these changes, and 3) clarify the association of these changes with mother-infant bonding. METHODS: This study used a longitudinal observational design and questionnaires to obtain objective and subjective data. For oxytocin evaluation, saliva samples were collected and their oxytocin levels were measured at 4-time points [i.e., 1) 36–37 gestation weeks, 2) 38–39 gestation weeks, 3) 1–2 days postpartum, 4) 4–5 days postpartum]. The oxytocin level was assayed in duplicates by enzyme-linked immunosorbent assay. Baseline data were evaluated using the Parental Bonding Instrument (25 items), State Trait Anxiety Inventory (20 items), and Center for Epidemiologic Studies Depression Scale. Postpartum data were evaluated using the Mother to Infant Bonding Scale Japanese Version (10 items), Maternity Blues Scale (13 items), and ‘Fatigue after Childbirth’ using the Visual Analogue Scale (VAS: 0–100 mm). RESULTS: The participants were 13 primiparas with a mean age of 33 years. They had no depression or anxiety at the baseline. Their mean salivary oxytocin levels significantly increased from late pregnancy (36–39 gestation weeks) up to 1 day postpartum and then decreased until 5 days postpartum. There was a negligible correlation between the bonding disorder and the salivary oxytocin level on the 5th day after childbirth. A moderate correlation was observed between the maternity blues score and the salivary oxytocin level. There was a significant negative correlation between the postpartum fatigue and the salivary oxytocin level 1 day and 5 days after childbirth. CONCLUSION: The mean salivary oxytocin levels significantly increased from the baseline up to 1 day postpartum and then decreased until 5 days postpartum. The salivary oxytocin level was moderately associated with maternity blues and significantly with postpartum fatigue. Public Library of Science 2019-09-03 /pmc/articles/PMC6719851/ /pubmed/31479475 http://dx.doi.org/10.1371/journal.pone.0221821 Text en © 2019 Shishido et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shishido, Eri
Shuo, Takuya
Takahata, Kaori
Horiuchi, Shigeko
Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study
title Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study
title_full Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study
title_fullStr Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study
title_full_unstemmed Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study
title_short Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study
title_sort changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719851/
https://www.ncbi.nlm.nih.gov/pubmed/31479475
http://dx.doi.org/10.1371/journal.pone.0221821
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