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The molecular determinants of R-roscovitine block of hERG channels
Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (I(Kr)) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K(+)channels and can trap many unintended drugs, often res...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719874/ https://www.ncbi.nlm.nih.gov/pubmed/31479461 http://dx.doi.org/10.1371/journal.pone.0217733 |