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Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and func...

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Detalles Bibliográficos
Autores principales: Xu, Junpeng, Liu, Yi, Hsu, Shan-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720009/
https://www.ncbi.nlm.nih.gov/pubmed/31430954
http://dx.doi.org/10.3390/molecules24163005
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author Xu, Junpeng
Liu, Yi
Hsu, Shan-hui
author_facet Xu, Junpeng
Liu, Yi
Hsu, Shan-hui
author_sort Xu, Junpeng
collection PubMed
description Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors.
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spelling pubmed-67200092019-09-10 Hydrogels Based on Schiff Base Linkages for Biomedical Applications Xu, Junpeng Liu, Yi Hsu, Shan-hui Molecules Review Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors. MDPI 2019-08-19 /pmc/articles/PMC6720009/ /pubmed/31430954 http://dx.doi.org/10.3390/molecules24163005 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Junpeng
Liu, Yi
Hsu, Shan-hui
Hydrogels Based on Schiff Base Linkages for Biomedical Applications
title Hydrogels Based on Schiff Base Linkages for Biomedical Applications
title_full Hydrogels Based on Schiff Base Linkages for Biomedical Applications
title_fullStr Hydrogels Based on Schiff Base Linkages for Biomedical Applications
title_full_unstemmed Hydrogels Based on Schiff Base Linkages for Biomedical Applications
title_short Hydrogels Based on Schiff Base Linkages for Biomedical Applications
title_sort hydrogels based on schiff base linkages for biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720009/
https://www.ncbi.nlm.nih.gov/pubmed/31430954
http://dx.doi.org/10.3390/molecules24163005
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AT liuyi hydrogelsbasedonschiffbaselinkagesforbiomedicalapplications
AT hsushanhui hydrogelsbasedonschiffbaselinkagesforbiomedicalapplications