Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis...

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Detalles Bibliográficos
Autores principales: Zhao, Xing, Cai, Yujie, Xu, Jianzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720291/
https://www.ncbi.nlm.nih.gov/pubmed/31412535
http://dx.doi.org/10.3390/ijms20163926
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author Zhao, Xing
Cai, Yujie
Xu, Jianzhen
author_facet Zhao, Xing
Cai, Yujie
Xu, Jianzhen
author_sort Zhao, Xing
collection PubMed
description CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.
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spelling pubmed-67202912019-10-30 Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers Zhao, Xing Cai, Yujie Xu, Jianzhen Int J Mol Sci Review CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed. MDPI 2019-08-13 /pmc/articles/PMC6720291/ /pubmed/31412535 http://dx.doi.org/10.3390/ijms20163926 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Xing
Cai, Yujie
Xu, Jianzhen
Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers
title Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers
title_full Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers
title_fullStr Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers
title_full_unstemmed Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers
title_short Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers
title_sort circular rnas: biogenesis, mechanism, and function in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720291/
https://www.ncbi.nlm.nih.gov/pubmed/31412535
http://dx.doi.org/10.3390/ijms20163926
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AT xujianzhen circularrnasbiogenesismechanismandfunctioninhumancancers

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