Cargando…

C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey

OBJECTIVE: Plasma C reactive protein (CRP) is a marker of inflammation, and increased plasma CRP is reported in many diseases, including cardiovascular disease, diabetes, metabolic syndrome, arthritis and malignancies. The aim of the study was to evaluate the association between plasma CRP levels an...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Hyemin, Baek, Sun-Young, Kim, Seon Woo, Park, Eun-Jung, Lee, Jaejoon, Kim, Hyungjin, Jeon, Chan Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720331/
https://www.ncbi.nlm.nih.gov/pubmed/31473619
http://dx.doi.org/10.1136/bmjopen-2019-029861
_version_ 1783448101193777152
author Jeong, Hyemin
Baek, Sun-Young
Kim, Seon Woo
Park, Eun-Jung
Lee, Jaejoon
Kim, Hyungjin
Jeon, Chan Hong
author_facet Jeong, Hyemin
Baek, Sun-Young
Kim, Seon Woo
Park, Eun-Jung
Lee, Jaejoon
Kim, Hyungjin
Jeon, Chan Hong
author_sort Jeong, Hyemin
collection PubMed
description OBJECTIVE: Plasma C reactive protein (CRP) is a marker of inflammation, and increased plasma CRP is reported in many diseases, including cardiovascular disease, diabetes, metabolic syndrome, arthritis and malignancies. The aim of the study was to evaluate the association between plasma CRP levels and cardiovascular disease, metabolic syndrome, malignancies and other comorbidities. DESIGN: A retrospective, cross-sectional survey study. SETTING: Large population survey in Korea. METHODS: A total of 5887 (weighted n=40 251 868) participants aged 19 years or older from the 2016 Korea National Health and Nutrition Examination Survey were included for analysis. Weighted prevalence and OR of comorbidities were analysed according to the continuous variable of log plasma high-sensitivity CRP levels. RESULTS: The mean age was 46.7±0.37 years and the median plasma CRP was 0.58 mg/L (IQR 0.36–1.09). The mean plasma CRP levels were higher in participants with cardiovascular diseases and cardiovascular risk factors, osteoarthritis, rheumatoid arthritis, pulmonary tuberculosis, and several cancers, including gastric, colon, breast and cervix, than in the general population. In the multivariable analysis, plasma CRP concentration was associated with increased prevalence of hypertriglyceridaemia (OR 1.157, 95% CI 1.040 to 1.287, p=0.007), diabetes (OR 1.204, 95% CI 1.058 to 1.371, p=0.005) and metabolic syndrome (OR 1.228, 95% CI 1.112 to 1.357, p<0.001) after adjustment for socioeconomic and lifestyle characteristics. There was no significant association between plasma CRP level and cancers. CONCLUSION: Plasma CRP was associated with an increased risk of dyslipidaemia, diabetes and metabolic syndrome in the general population.
format Online
Article
Text
id pubmed-6720331
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-67203312019-09-17 C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey Jeong, Hyemin Baek, Sun-Young Kim, Seon Woo Park, Eun-Jung Lee, Jaejoon Kim, Hyungjin Jeon, Chan Hong BMJ Open Epidemiology OBJECTIVE: Plasma C reactive protein (CRP) is a marker of inflammation, and increased plasma CRP is reported in many diseases, including cardiovascular disease, diabetes, metabolic syndrome, arthritis and malignancies. The aim of the study was to evaluate the association between plasma CRP levels and cardiovascular disease, metabolic syndrome, malignancies and other comorbidities. DESIGN: A retrospective, cross-sectional survey study. SETTING: Large population survey in Korea. METHODS: A total of 5887 (weighted n=40 251 868) participants aged 19 years or older from the 2016 Korea National Health and Nutrition Examination Survey were included for analysis. Weighted prevalence and OR of comorbidities were analysed according to the continuous variable of log plasma high-sensitivity CRP levels. RESULTS: The mean age was 46.7±0.37 years and the median plasma CRP was 0.58 mg/L (IQR 0.36–1.09). The mean plasma CRP levels were higher in participants with cardiovascular diseases and cardiovascular risk factors, osteoarthritis, rheumatoid arthritis, pulmonary tuberculosis, and several cancers, including gastric, colon, breast and cervix, than in the general population. In the multivariable analysis, plasma CRP concentration was associated with increased prevalence of hypertriglyceridaemia (OR 1.157, 95% CI 1.040 to 1.287, p=0.007), diabetes (OR 1.204, 95% CI 1.058 to 1.371, p=0.005) and metabolic syndrome (OR 1.228, 95% CI 1.112 to 1.357, p<0.001) after adjustment for socioeconomic and lifestyle characteristics. There was no significant association between plasma CRP level and cancers. CONCLUSION: Plasma CRP was associated with an increased risk of dyslipidaemia, diabetes and metabolic syndrome in the general population. BMJ Publishing Group 2019-08-30 /pmc/articles/PMC6720331/ /pubmed/31473619 http://dx.doi.org/10.1136/bmjopen-2019-029861 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Jeong, Hyemin
Baek, Sun-Young
Kim, Seon Woo
Park, Eun-Jung
Lee, Jaejoon
Kim, Hyungjin
Jeon, Chan Hong
C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey
title C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey
title_full C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey
title_fullStr C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey
title_full_unstemmed C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey
title_short C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey
title_sort c reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the korea national health and nutrition examination survey
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720331/
https://www.ncbi.nlm.nih.gov/pubmed/31473619
http://dx.doi.org/10.1136/bmjopen-2019-029861
work_keys_str_mv AT jeonghyemin creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey
AT baeksunyoung creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey
AT kimseonwoo creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey
AT parkeunjung creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey
AT leejaejoon creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey
AT kimhyungjin creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey
AT jeonchanhong creactiveproteinlevelasamarkerfordyslipidaemiadiabetesandmetabolicsyndromeresultsfromthekoreanationalhealthandnutritionexaminationsurvey