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The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study
PURPOSE: The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720339/ https://www.ncbi.nlm.nih.gov/pubmed/31467051 http://dx.doi.org/10.1136/bmjopen-2018-028866 |
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author | Iliadou, Anastasia N Öberg, Anna Sara Pege, Jessica Rodriguez-Wallberg, Kenny A Olofsson, Jan I Holte, Jan Wramsby, Håkan Wramsby, Margaretha Cnattingius, Sven Cesta, Carolyn E |
author_facet | Iliadou, Anastasia N Öberg, Anna Sara Pege, Jessica Rodriguez-Wallberg, Kenny A Olofsson, Jan I Holte, Jan Wramsby, Håkan Wramsby, Margaretha Cnattingius, Sven Cesta, Carolyn E |
author_sort | Iliadou, Anastasia N |
collection | PubMed |
description | PURPOSE: The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome. PARTICIPANTS: Recruitment took place between September 2011 and December 2013, and in vitro fertilisation (IVF) cycles initiated and pregnancies conceived during this time were followed until December 2014. The cohort includes 971 participants (n= 514 women; n= 457 men), and 129 pregnancies were achieved from the first IVF cycle included in the study. FINDINGS TO DATE: Self-reported demographic, health and lifestyle data were collected from a baseline questionnaire, and to assess changes to lifestyle, a follow-up questionnaire was issued at the time of oocyte retrieval, and at subsequent IVF cycles. Questionnaire data were linked to data extracted from medical records. Biological samples were collected at baseline: blood for extraction of serum, plasma and DNA, morning and evening saliva samples for cortisol measurement and at delivery including samples of maternal blood, placenta and amniotic fluid, and cord blood for epigenetic analysis. FUTURE PLANS: Through the unique identification number assigned to each Swedish citizen at birth or immigration, UppStART study participants will be linked to the Swedish population-based national and quality registers to provide data from prenatal, obstetrical, neonatal and infant care, and subsequent updates will provide data on childhood health and educational outcomes. Collaboration and use of UppStART data is encouraged, and more information about access can be found at www.ki.se/meb/uppstart |
format | Online Article Text |
id | pubmed-6720339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-67203392019-09-17 The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study Iliadou, Anastasia N Öberg, Anna Sara Pege, Jessica Rodriguez-Wallberg, Kenny A Olofsson, Jan I Holte, Jan Wramsby, Håkan Wramsby, Margaretha Cnattingius, Sven Cesta, Carolyn E BMJ Open Reproductive Medicine PURPOSE: The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome. PARTICIPANTS: Recruitment took place between September 2011 and December 2013, and in vitro fertilisation (IVF) cycles initiated and pregnancies conceived during this time were followed until December 2014. The cohort includes 971 participants (n= 514 women; n= 457 men), and 129 pregnancies were achieved from the first IVF cycle included in the study. FINDINGS TO DATE: Self-reported demographic, health and lifestyle data were collected from a baseline questionnaire, and to assess changes to lifestyle, a follow-up questionnaire was issued at the time of oocyte retrieval, and at subsequent IVF cycles. Questionnaire data were linked to data extracted from medical records. Biological samples were collected at baseline: blood for extraction of serum, plasma and DNA, morning and evening saliva samples for cortisol measurement and at delivery including samples of maternal blood, placenta and amniotic fluid, and cord blood for epigenetic analysis. FUTURE PLANS: Through the unique identification number assigned to each Swedish citizen at birth or immigration, UppStART study participants will be linked to the Swedish population-based national and quality registers to provide data from prenatal, obstetrical, neonatal and infant care, and subsequent updates will provide data on childhood health and educational outcomes. Collaboration and use of UppStART data is encouraged, and more information about access can be found at www.ki.se/meb/uppstart BMJ Publishing Group 2019-08-28 /pmc/articles/PMC6720339/ /pubmed/31467051 http://dx.doi.org/10.1136/bmjopen-2018-028866 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Reproductive Medicine Iliadou, Anastasia N Öberg, Anna Sara Pege, Jessica Rodriguez-Wallberg, Kenny A Olofsson, Jan I Holte, Jan Wramsby, Håkan Wramsby, Margaretha Cnattingius, Sven Cesta, Carolyn E The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study |
title | The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study |
title_full | The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study |
title_fullStr | The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study |
title_full_unstemmed | The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study |
title_short | The Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study |
title_sort | uppsala–stockholm assisted reproductive techniques (uppstart) study |
topic | Reproductive Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720339/ https://www.ncbi.nlm.nih.gov/pubmed/31467051 http://dx.doi.org/10.1136/bmjopen-2018-028866 |
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