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Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945

Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins). Dysregulation of this processes is linked with various diseases including cancers, neurodegenerative diseases, and many genetic...

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Detalles Bibliográficos
Autores principales:	Lee, Joo Youn, Yun, Ji-Sook, Kim, Woo-Keun, Chun, Hang-Suk, Jin, Hyeonseok, Cho, Sungchan, Chang, Jeong Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720368/ https://www.ncbi.nlm.nih.gov/pubmed/31531359 http://dx.doi.org/10.1155/2019/6125068

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