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Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review
Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approac...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720397/ https://www.ncbi.nlm.nih.gov/pubmed/31508598 http://dx.doi.org/10.1186/s13065-019-0611-x |
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author | Xu, Li Wen, Yanli Pandit, Santosh Mokkapati, Venkata R. S. S. Mijakovic, Ivan Li, Yan Ding, Min Ren, Shuzhen Li, Wen Liu, Gang |
author_facet | Xu, Li Wen, Yanli Pandit, Santosh Mokkapati, Venkata R. S. S. Mijakovic, Ivan Li, Yan Ding, Min Ren, Shuzhen Li, Wen Liu, Gang |
author_sort | Xu, Li |
collection | PubMed |
description | Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities. |
format | Online Article Text |
id | pubmed-6720397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-67203972019-09-10 Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review Xu, Li Wen, Yanli Pandit, Santosh Mokkapati, Venkata R. S. S. Mijakovic, Ivan Li, Yan Ding, Min Ren, Shuzhen Li, Wen Liu, Gang BMC Chem Mini Review Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities. Springer International Publishing 2019-09-03 /pmc/articles/PMC6720397/ /pubmed/31508598 http://dx.doi.org/10.1186/s13065-019-0611-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Mini Review Xu, Li Wen, Yanli Pandit, Santosh Mokkapati, Venkata R. S. S. Mijakovic, Ivan Li, Yan Ding, Min Ren, Shuzhen Li, Wen Liu, Gang Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
title | Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
title_full | Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
title_fullStr | Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
title_full_unstemmed | Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
title_short | Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
title_sort | graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720397/ https://www.ncbi.nlm.nih.gov/pubmed/31508598 http://dx.doi.org/10.1186/s13065-019-0611-x |
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