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Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population

BACKGROUND: Single nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of these SNPs in Jordanian BC patients. Therefore, this study aims to determine if t...

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Autores principales: AL-Eitan, Laith N., Rababa’h, Doaa M., Alghamdi, Mansour A., Khasawneh, Rame H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720417/
https://www.ncbi.nlm.nih.gov/pubmed/31477036
http://dx.doi.org/10.1186/s12881-019-0884-x
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author AL-Eitan, Laith N.
Rababa’h, Doaa M.
Alghamdi, Mansour A.
Khasawneh, Rame H.
author_facet AL-Eitan, Laith N.
Rababa’h, Doaa M.
Alghamdi, Mansour A.
Khasawneh, Rame H.
author_sort AL-Eitan, Laith N.
collection PubMed
description BACKGROUND: Single nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of these SNPs in Jordanian BC patients. Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population. In addition, this work investigates the association between selected BC prognostic factors and variants of the aforementioned CYP candidate genes. METHODS: Blood samples were withdrawn from 221 BC patients and 218 healthy volunteers recruited from the Jordanian population. Genomic DNA was withdrawn and, after quantification and quality control, was genotyped using the Sequenom MassARRAY® system (iPLEX GOLD). Statistical analysis was then carried out to assess allelic and genotypic frequencies as well as genetic association between cases and controls. RESULTS: The CYP19A1 SNP rs7176005 (p < 0.0045) and the CYP1A2 SNP rs762551 (p = 0.004) were significantly associated with BC risk. However, no such association was found for the screened SNPs of the CYP2C9, CYP1B1, CYP2C19 and CYP3A4 genes. Regarding the prognostic factors of BC, several of the screened SNPs were associated with different pathological and clinical features. CONCLUSIONS: Certain CYP genes, particularly CYP19A1 and CYP1A2, were associated with BC risk and development in the Jordanian population.
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spelling pubmed-67204172019-09-06 Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population AL-Eitan, Laith N. Rababa’h, Doaa M. Alghamdi, Mansour A. Khasawneh, Rame H. BMC Med Genet Research Article BACKGROUND: Single nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of these SNPs in Jordanian BC patients. Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population. In addition, this work investigates the association between selected BC prognostic factors and variants of the aforementioned CYP candidate genes. METHODS: Blood samples were withdrawn from 221 BC patients and 218 healthy volunteers recruited from the Jordanian population. Genomic DNA was withdrawn and, after quantification and quality control, was genotyped using the Sequenom MassARRAY® system (iPLEX GOLD). Statistical analysis was then carried out to assess allelic and genotypic frequencies as well as genetic association between cases and controls. RESULTS: The CYP19A1 SNP rs7176005 (p < 0.0045) and the CYP1A2 SNP rs762551 (p = 0.004) were significantly associated with BC risk. However, no such association was found for the screened SNPs of the CYP2C9, CYP1B1, CYP2C19 and CYP3A4 genes. Regarding the prognostic factors of BC, several of the screened SNPs were associated with different pathological and clinical features. CONCLUSIONS: Certain CYP genes, particularly CYP19A1 and CYP1A2, were associated with BC risk and development in the Jordanian population. BioMed Central 2019-09-02 /pmc/articles/PMC6720417/ /pubmed/31477036 http://dx.doi.org/10.1186/s12881-019-0884-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
AL-Eitan, Laith N.
Rababa’h, Doaa M.
Alghamdi, Mansour A.
Khasawneh, Rame H.
Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
title Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
title_full Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
title_fullStr Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
title_full_unstemmed Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
title_short Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
title_sort association of cyp gene polymorphisms with breast cancer risk and prognostic factors in the jordanian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720417/
https://www.ncbi.nlm.nih.gov/pubmed/31477036
http://dx.doi.org/10.1186/s12881-019-0884-x
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