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Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome?
BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric variables and insulin resistance in women with and without PCOS and investigate the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720418/ https://www.ncbi.nlm.nih.gov/pubmed/31477085 http://dx.doi.org/10.1186/s12902-019-0420-1 |
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author | Shishehgar, Farnaz Mirmiran, Parvin Rahmati, Maryam Tohidi, Maryam Ramezani Tehrani, Fahimeh |
author_facet | Shishehgar, Farnaz Mirmiran, Parvin Rahmati, Maryam Tohidi, Maryam Ramezani Tehrani, Fahimeh |
author_sort | Shishehgar, Farnaz |
collection | PubMed |
description | BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric variables and insulin resistance in women with and without PCOS and investigate the effect of this diet on the clinical and hormonal features of PCOS women. METHODS: This interventional study was carried out at the Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Of 108 women invited for the purpose of the present study, 62 participants (PCOS = 28, non-PCOS = 34) followed a 24-week energy restricted LGI diet. Anthropometric, biochemical, hormonal and clinical measurements were documented at baseline, 12 weeks and 24 weeks with intervention. RESULTS: The percentages of weight loss achieved by both the PCOS and non-PCOS groups did not differ significantly (PCOS: -8.04% vs. non-PCOS: -8.09%). No significant difference in decrease of homeostatic model assessment of insulin resistance (HOMA-IR) was observed between the two groups (PCOS = − 0.83 ± 0.33, non PCOS = − 0.79 ± 0.28, P = 0.83). In PCOS women, significant reduction in total testosterone (− 0.91 ± 0.33 nmol/L, P = 0.006), FAI (− 4.47 ± 1.1, P < 0.001) and increase in SHBG (38.98 ± 11.02 nmol/L, P < 0.001) were observed. Menstrual irregularity was improved in 80% of women with PCOS and a significant decrease (32.1%) in occurrence of acne was reported. CONCLUSIONS: This diet has equally beneficial effects on anthropometric and metabolic characteristics of overweight women with and without PCOS. TRIAL REGISTRATION: This study is registered in the Iranian Randomized Clinical Trials Registry (IRCT, code: IRCT2016092129909N1). |
format | Online Article Text |
id | pubmed-6720418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67204182019-09-06 Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? Shishehgar, Farnaz Mirmiran, Parvin Rahmati, Maryam Tohidi, Maryam Ramezani Tehrani, Fahimeh BMC Endocr Disord Research Article BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric variables and insulin resistance in women with and without PCOS and investigate the effect of this diet on the clinical and hormonal features of PCOS women. METHODS: This interventional study was carried out at the Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Of 108 women invited for the purpose of the present study, 62 participants (PCOS = 28, non-PCOS = 34) followed a 24-week energy restricted LGI diet. Anthropometric, biochemical, hormonal and clinical measurements were documented at baseline, 12 weeks and 24 weeks with intervention. RESULTS: The percentages of weight loss achieved by both the PCOS and non-PCOS groups did not differ significantly (PCOS: -8.04% vs. non-PCOS: -8.09%). No significant difference in decrease of homeostatic model assessment of insulin resistance (HOMA-IR) was observed between the two groups (PCOS = − 0.83 ± 0.33, non PCOS = − 0.79 ± 0.28, P = 0.83). In PCOS women, significant reduction in total testosterone (− 0.91 ± 0.33 nmol/L, P = 0.006), FAI (− 4.47 ± 1.1, P < 0.001) and increase in SHBG (38.98 ± 11.02 nmol/L, P < 0.001) were observed. Menstrual irregularity was improved in 80% of women with PCOS and a significant decrease (32.1%) in occurrence of acne was reported. CONCLUSIONS: This diet has equally beneficial effects on anthropometric and metabolic characteristics of overweight women with and without PCOS. TRIAL REGISTRATION: This study is registered in the Iranian Randomized Clinical Trials Registry (IRCT, code: IRCT2016092129909N1). BioMed Central 2019-09-02 /pmc/articles/PMC6720418/ /pubmed/31477085 http://dx.doi.org/10.1186/s12902-019-0420-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Shishehgar, Farnaz Mirmiran, Parvin Rahmati, Maryam Tohidi, Maryam Ramezani Tehrani, Fahimeh Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
title | Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
title_full | Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
title_fullStr | Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
title_full_unstemmed | Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
title_short | Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
title_sort | does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720418/ https://www.ncbi.nlm.nih.gov/pubmed/31477085 http://dx.doi.org/10.1186/s12902-019-0420-1 |
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