Cargando…

CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

BACKGROUND: Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-dependen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiangyu, Wang, Jiali, Jia, Yunlong, Liu, Tianxu, Wang, Mengjie, Lv, Wei, Zhang, Rong, Shi, Juan, Liu, Lihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720419/ https://www.ncbi.nlm.nih.gov/pubmed/31496920 http://dx.doi.org/10.1186/s12935-019-0952-5

Ejemplares similares

Cdk5-mediated Phosphorylation of c-Myc on Ser-62 Is Essential in Transcriptional Activation of Cyclin B1 by Cyclin G1
por: Seo, Haeng Ran, et al.
Publicado: (2008)

LncRNA TTN-AS1 promotes migration, invasion, and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5
por: Jia, Yunlong, et al.
Publicado: (2019)

Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p
por: Lv, Wei, et al.
Publicado: (2022)

MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6
por: Shao, Yuan, et al.
Publicado: (2013)

Convergent lines of evidence support BIN1 as a risk gene of Alzheimer’s disease
por: Zhu, Jin, et al.
Publicado: (2021)

Phosphorylation of the androgen receptor at Ser81 is co‐sustained by CDK1 and CDK9 and leads to AR‐mediated transactivation in prostate cancer
por: Gao, XinTao, et al.
Publicado: (2021)

Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc
por: Raman, Deepika, et al.
Publicado: (2020)

T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62
por: Daniel, Colin J., et al.
Publicado: (2022)

Methylation decreases the Bin1 tumor suppressor in ESCC and restoration by decitabine inhibits the epithelial mesenchymal transition
por: Wang, Xuexiao, et al.
Publicado: (2017)

p62 acts as an oncogene and is targeted by miR-124-3p in glioma
por: Deng, Danni, et al.
Publicado: (2019)

Ser-634 and Ser-636 of Kaposi’s Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites
por: Tsai, Wan-Hua, et al.
Publicado: (2012)

Molecular mechanism of G(1) arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells
por: Tao, Yan-Fang, et al.
Publicado: (2017)

RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG(2) human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell
por: Zhao, Yan, et al.
Publicado: (2013)

Abnormal expression of CDK11(p58) in prostate cancer
por: Chi, Yayun, et al.
Publicado: (2014)

Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351
por: Park, Jee-Yun, et al.
Publicado: (2021)

Cisplatin loaded multiwalled carbon nanotubes reverse drug resistance in NSCLC by inhibiting EMT
por: Qi, Yuxin, et al.
Publicado: (2021)

Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma
por: Rihani, Ali, et al.
Publicado: (2015)

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27
por: García-Gutiérrez, Lucía, et al.
Publicado: (2019)

MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma
por: Zhang, Jun-feng, et al.
Publicado: (2018)

Alkaline phosphatase downregulation promotes lung adenocarcinoma metastasis via the c-Myc/RhoA axis
por: Lou, Zhefeng, et al.
Publicado: (2021)

DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling
por: Yu, Wandong, et al.
Publicado: (2021)

The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
por: Mao, Cheng-Gang, et al.
Publicado: (2020)

X-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of Cdk5 and p25
por: Sun, Ai-Min, et al.
Publicado: (2013)

MiR-937-3p promotes metastasis and angiogenesis and is activated by MYC in lung adenocarcinoma
por: Ma, Zijian, et al.
Publicado: (2022)

Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells
por: Huang, Jing, et al.
Publicado: (2019)

circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene
por: Qu, Xinhua, et al.
Publicado: (2020)

LncRNA SNHG12 regulates the radiosensitivity of cervical cancer through the miR-148a/CDK1 pathway
por: Wang, Chen, et al.
Publicado: (2020)

EF24 exerts cytotoxicity against NSCLC via inducing ROS accumulation
por: Chang, Minghui, et al.
Publicado: (2021)

The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance
por: Li, Tiezhi, et al.
Publicado: (2022)

microRNA‐211 promotes proliferation, migration, and invasion ability of oral squamous cell carcinoma cells via targeting the bridging integrator 1 protein
por: Zheng, Jiabao, et al.
Publicado: (2018)

LncRNA ASAP1-IT1 enhances cancer cell stemness via regulating miR-509-3p/YAP1 axis in NSCLC
por: Liu, Yantao, et al.
Publicado: (2021)

AL355338 acts as an oncogenic lncRNA by interacting with protein ENO1 to regulate EGFR/AKT pathway in NSCLC
por: Hua, Qian, et al.
Publicado: (2021)

CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro
por: He, Xiangming, et al.
Publicado: (2014)

Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling
por: Zhou, Ji, et al.
Publicado: (2021)

BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes
por: Wu, Shuiyan, et al.
Publicado: (2021)

LncRNA OGFRP1 acts as an oncogene in NSCLC via miR-4640-5p/eIF5A axis
por: Liu, Xiaojing, et al.
Publicado: (2021)

CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling
por: Lin, Jian-Xian, et al.
Publicado: (2019)

Hsa_circ_0068307 mediates bladder cancer stem cell-like properties via miR-147/c-Myc axis regulation
por: Chen, Qi, et al.
Publicado: (2020)

SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
por: Wang, Shaoqiang, et al.
Publicado: (2018)

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
por: Zeng, Mei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_u7dkj0qokoj5f9sb1odvrfsoh7