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CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

BACKGROUND: Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-dependen...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiangyu, Wang, Jiali, Jia, Yunlong, Liu, Tianxu, Wang, Mengjie, Lv, Wei, Zhang, Rong, Shi, Juan, Liu, Lihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720419/ https://www.ncbi.nlm.nih.gov/pubmed/31496920 http://dx.doi.org/10.1186/s12935-019-0952-5

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