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Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction

A simplified substitute for heart rate (HR) at the anaerobic threshold (AT), i.e., resting HR plus 30 beats per minute or a percentage of predicted maximum HR, is used as a way to determine exercise intensity without cardiopulmonary exercise testing (CPX) data. However, difficulties arise when using...

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Autores principales: Nemoto, Shinji, Kasahara, Yusuke, Izawa, Kazuhiro P., Watanabe, Satoshi, Yoshizawa, Kazuya, Takeichi, Naoya, Kamiya, Kentaro, Suzuki, Norio, Omiya, Kazuto, Matsunaga, Atsuhiko, Akashi, Yoshihiro J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720421/
https://www.ncbi.nlm.nih.gov/pubmed/31398919
http://dx.doi.org/10.3390/ijerph16162838
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author Nemoto, Shinji
Kasahara, Yusuke
Izawa, Kazuhiro P.
Watanabe, Satoshi
Yoshizawa, Kazuya
Takeichi, Naoya
Kamiya, Kentaro
Suzuki, Norio
Omiya, Kazuto
Matsunaga, Atsuhiko
Akashi, Yoshihiro J.
author_facet Nemoto, Shinji
Kasahara, Yusuke
Izawa, Kazuhiro P.
Watanabe, Satoshi
Yoshizawa, Kazuya
Takeichi, Naoya
Kamiya, Kentaro
Suzuki, Norio
Omiya, Kazuto
Matsunaga, Atsuhiko
Akashi, Yoshihiro J.
author_sort Nemoto, Shinji
collection PubMed
description A simplified substitute for heart rate (HR) at the anaerobic threshold (AT), i.e., resting HR plus 30 beats per minute or a percentage of predicted maximum HR, is used as a way to determine exercise intensity without cardiopulmonary exercise testing (CPX) data. However, difficulties arise when using this method in subacute myocardial infarction (MI) patients undergoing beta-blocker therapy. This study compared the effects of αβ-blocker and β1-blocker treatment to clarify how different beta blockers affect HR response during incremental exercise. MI patients were divided into αβ-blocker (n = 67), β1-blocker (n = 17), and no-β-blocker (n = 47) groups. All patients underwent CPX one month after MI onset. The metabolic chronotropic relationship (MCR) was calculated as an indicator of HR response from the ratio of estimated HR to measured HR at AT (MCR-AT) and peak exercise (MCR-peak). MCR-AT and MCR-peak were significantly higher in the αβ-blocker group than in the β1-blocker group (p < 0.001, respectively). Multiple regression analysis revealed that β1-blocker but not αβ-blocker treatment significantly predicted lower MCR-AT and MCR-peak (β = −0.432, p < 0.001; β = −0.473, p < 0.001, respectively). Based on these results, when using the simplified method, exercise intensity should be prescribed according to the type of beta blocker used.
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spelling pubmed-67204212019-09-10 Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction Nemoto, Shinji Kasahara, Yusuke Izawa, Kazuhiro P. Watanabe, Satoshi Yoshizawa, Kazuya Takeichi, Naoya Kamiya, Kentaro Suzuki, Norio Omiya, Kazuto Matsunaga, Atsuhiko Akashi, Yoshihiro J. Int J Environ Res Public Health Article A simplified substitute for heart rate (HR) at the anaerobic threshold (AT), i.e., resting HR plus 30 beats per minute or a percentage of predicted maximum HR, is used as a way to determine exercise intensity without cardiopulmonary exercise testing (CPX) data. However, difficulties arise when using this method in subacute myocardial infarction (MI) patients undergoing beta-blocker therapy. This study compared the effects of αβ-blocker and β1-blocker treatment to clarify how different beta blockers affect HR response during incremental exercise. MI patients were divided into αβ-blocker (n = 67), β1-blocker (n = 17), and no-β-blocker (n = 47) groups. All patients underwent CPX one month after MI onset. The metabolic chronotropic relationship (MCR) was calculated as an indicator of HR response from the ratio of estimated HR to measured HR at AT (MCR-AT) and peak exercise (MCR-peak). MCR-AT and MCR-peak were significantly higher in the αβ-blocker group than in the β1-blocker group (p < 0.001, respectively). Multiple regression analysis revealed that β1-blocker but not αβ-blocker treatment significantly predicted lower MCR-AT and MCR-peak (β = −0.432, p < 0.001; β = −0.473, p < 0.001, respectively). Based on these results, when using the simplified method, exercise intensity should be prescribed according to the type of beta blocker used. MDPI 2019-08-08 2019-08 /pmc/articles/PMC6720421/ /pubmed/31398919 http://dx.doi.org/10.3390/ijerph16162838 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nemoto, Shinji
Kasahara, Yusuke
Izawa, Kazuhiro P.
Watanabe, Satoshi
Yoshizawa, Kazuya
Takeichi, Naoya
Kamiya, Kentaro
Suzuki, Norio
Omiya, Kazuto
Matsunaga, Atsuhiko
Akashi, Yoshihiro J.
Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
title Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
title_full Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
title_fullStr Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
title_full_unstemmed Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
title_short Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
title_sort effects of αβ-blocker versus β1-blocker treatment on heart rate response during incremental cardiopulmonary exercise in japanese male patients with subacute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720421/
https://www.ncbi.nlm.nih.gov/pubmed/31398919
http://dx.doi.org/10.3390/ijerph16162838
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