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Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

BTB-Kelch proteins form the largest subfamily of Cullin-RING E3 ligases, yet their substrate complexes are mapped and structurally characterized only for KEAP1 and KLHL3. KLHL20 is a related CUL3-dependent ubiquitin ligase linked to autophagy, cancer, and Alzheimer's disease that promotes the u...

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Detalles Bibliográficos
Autores principales:	Chen, Zhuoyao, Picaud, Sarah, Filippakopoulos, Panagis, D'Angiolella, Vincenzo, Bullock, Alex N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720452/ https://www.ncbi.nlm.nih.gov/pubmed/31279627 http://dx.doi.org/10.1016/j.str.2019.06.005

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