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Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components

Since the 50’s, the massive and “environmental naïve” use of synthetic chemistry has revolutionized the farming community facing the dramatic growth of demography. However, nowadays, the controversy grows regarding the long-term harmful effects of these products on human health and the environment....

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Autores principales: Lins, Laurence, Dal Maso, Simon, Foncoux, Berenice, Kamili, Anouar, Laurin, Yoann, Genva, Manon, Jijakli, M. Haissam, De Clerck, Caroline, Fauconnier, Marie Laure, Deleu, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720526/
https://www.ncbi.nlm.nih.gov/pubmed/31426453
http://dx.doi.org/10.3390/ijms20164007
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author Lins, Laurence
Dal Maso, Simon
Foncoux, Berenice
Kamili, Anouar
Laurin, Yoann
Genva, Manon
Jijakli, M. Haissam
De Clerck, Caroline
Fauconnier, Marie Laure
Deleu, Magali
author_facet Lins, Laurence
Dal Maso, Simon
Foncoux, Berenice
Kamili, Anouar
Laurin, Yoann
Genva, Manon
Jijakli, M. Haissam
De Clerck, Caroline
Fauconnier, Marie Laure
Deleu, Magali
author_sort Lins, Laurence
collection PubMed
description Since the 50’s, the massive and “environmental naïve” use of synthetic chemistry has revolutionized the farming community facing the dramatic growth of demography. However, nowadays, the controversy grows regarding the long-term harmful effects of these products on human health and the environment. In this context, the use of essential oils (EOs) could be an alternative to chemical products and a better understanding of their mode of biological action for new and optimal applications is of importance. Indeed, if the biocidal effects of some EOs or their components have been at least partly elucidated at the molecular level, very little is currently known regarding their mechanism of action as herbicides at the molecular level. Here, we showed that cinnamon and Java citronella essential oils and some of their main components, i.e.,, cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves. The individual EO molecules are small amphiphiles, allowing for them to cross the mesh of cell wall and directly interact with the plant plasma membrane (PPM), which is one of the potential cellular targets of EOs. Hence, we investigated and characterized their interaction with biomimetic PPM while using an integrative biophysical approach. If CitO and CitA, maintaining a similar chemical structure, are able to interact with the model membranes without permeabilizing effect, CIN belonging to the phenylpropanoid family, is not. We suggested that different mechanisms of action for the two types of molecules can occur: while the monoterpenes could disturb the lipid organization and/or domain formation, the phenylpropanoid CIN could interact with membrane receptors.
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spelling pubmed-67205262019-09-10 Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components Lins, Laurence Dal Maso, Simon Foncoux, Berenice Kamili, Anouar Laurin, Yoann Genva, Manon Jijakli, M. Haissam De Clerck, Caroline Fauconnier, Marie Laure Deleu, Magali Int J Mol Sci Article Since the 50’s, the massive and “environmental naïve” use of synthetic chemistry has revolutionized the farming community facing the dramatic growth of demography. However, nowadays, the controversy grows regarding the long-term harmful effects of these products on human health and the environment. In this context, the use of essential oils (EOs) could be an alternative to chemical products and a better understanding of their mode of biological action for new and optimal applications is of importance. Indeed, if the biocidal effects of some EOs or their components have been at least partly elucidated at the molecular level, very little is currently known regarding their mechanism of action as herbicides at the molecular level. Here, we showed that cinnamon and Java citronella essential oils and some of their main components, i.e.,, cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves. The individual EO molecules are small amphiphiles, allowing for them to cross the mesh of cell wall and directly interact with the plant plasma membrane (PPM), which is one of the potential cellular targets of EOs. Hence, we investigated and characterized their interaction with biomimetic PPM while using an integrative biophysical approach. If CitO and CitA, maintaining a similar chemical structure, are able to interact with the model membranes without permeabilizing effect, CIN belonging to the phenylpropanoid family, is not. We suggested that different mechanisms of action for the two types of molecules can occur: while the monoterpenes could disturb the lipid organization and/or domain formation, the phenylpropanoid CIN could interact with membrane receptors. MDPI 2019-08-16 /pmc/articles/PMC6720526/ /pubmed/31426453 http://dx.doi.org/10.3390/ijms20164007 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lins, Laurence
Dal Maso, Simon
Foncoux, Berenice
Kamili, Anouar
Laurin, Yoann
Genva, Manon
Jijakli, M. Haissam
De Clerck, Caroline
Fauconnier, Marie Laure
Deleu, Magali
Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components
title Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components
title_full Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components
title_fullStr Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components
title_full_unstemmed Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components
title_short Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components
title_sort insights into the relationships between herbicide activities, molecular structure and membrane interaction of cinnamon and citronella essential oils components
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720526/
https://www.ncbi.nlm.nih.gov/pubmed/31426453
http://dx.doi.org/10.3390/ijms20164007
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