One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones

Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxy...

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Autores principales: Yuan, Jiaqi, He, Qian, Song, Shanshan, Zhang, Xiaofei, Miao, Zehong, Yang, Chunhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720541/
https://www.ncbi.nlm.nih.gov/pubmed/31434258
http://dx.doi.org/10.3390/molecules24163017
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author Yuan, Jiaqi
He, Qian
Song, Shanshan
Zhang, Xiaofei
Miao, Zehong
Yang, Chunhao
author_facet Yuan, Jiaqi
He, Qian
Song, Shanshan
Zhang, Xiaofei
Miao, Zehong
Yang, Chunhao
author_sort Yuan, Jiaqi
collection PubMed
description Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.
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spelling pubmed-67205412019-09-10 One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones Yuan, Jiaqi He, Qian Song, Shanshan Zhang, Xiaofei Miao, Zehong Yang, Chunhao Molecules Article Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities. MDPI 2019-08-20 /pmc/articles/PMC6720541/ /pubmed/31434258 http://dx.doi.org/10.3390/molecules24163017 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Jiaqi
He, Qian
Song, Shanshan
Zhang, Xiaofei
Miao, Zehong
Yang, Chunhao
One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_full One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_fullStr One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_full_unstemmed One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_short One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_sort one pot and metal-free approach to 3-(2-hydroxybenzoyl)-1-aza-anthraquinones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720541/
https://www.ncbi.nlm.nih.gov/pubmed/31434258
http://dx.doi.org/10.3390/molecules24163017
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