Bipolenins K–N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

Chemical investigation of the barley and wheat fungal pathogen Bipolaris sorokiniana BRIP10943 yielded four new sativene-type sesquiterpenoid natural products, bipolenins K–N (1–4), together with seven related known analogues (5–11), and a sesterterpenoid (12). Their structures were determined by de...

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Detalles Bibliográficos
Autores principales: Phan, Chin-Soon, Li, Hang, Kessler, Simon, Solomon, Peter S, Piggott, Andrew M, Chooi, Yit-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720731/
https://www.ncbi.nlm.nih.gov/pubmed/31501669
http://dx.doi.org/10.3762/bjoc.15.198
Descripción
Sumario:Chemical investigation of the barley and wheat fungal pathogen Bipolaris sorokiniana BRIP10943 yielded four new sativene-type sesquiterpenoid natural products, bipolenins K–N (1–4), together with seven related known analogues (5–11), and a sesterterpenoid (12). Their structures were determined by detailed analysis of spectroscopic data, supported by TDDFT calculations and comparison with previously reported analogues. These compounds were evaluated for their phytotoxic activity against wheat seedlings and wheat seed germination. The putative biosynthetic relationships between the isolated sesquiterpenoids were also explored.

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